ID   KBP_DROME               Reviewed;         600 AA.
AC   Q9VMX1; Q6NP90;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=KIF-binding protein;
DE   AltName: Full=Protein KBP;
GN   ORFNames=CG14043;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q96EK5}.
CC   -!- SIMILARITY: Belongs to the KIF-binding protein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAR30198.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE014134; AAF52187.1; -; Genomic_DNA.
DR   EMBL; BT011038; AAR30198.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_608886.1; NM_135042.3.
DR   AlphaFoldDB; Q9VMX1; -.
DR   SMR; Q9VMX1; -.
DR   BioGRID; 59898; 1.
DR   IntAct; Q9VMX1; 2.
DR   STRING; 7227.FBpp0078634; -.
DR   PaxDb; Q9VMX1; -.
DR   PRIDE; Q9VMX1; -.
DR   DNASU; 33714; -.
DR   EnsemblMetazoa; FBtr0078995; FBpp0078634; FBgn0031659.
DR   GeneID; 33714; -.
DR   KEGG; dme:Dmel_CG14043; -.
DR   UCSC; CG14043-RA; d. melanogaster.
DR   FlyBase; FBgn0031659; CG14043.
DR   VEuPathDB; VectorBase:FBgn0031659; -.
DR   eggNOG; ENOG502QPZT; Eukaryota.
DR   GeneTree; ENSGT00390000013819; -.
DR   HOGENOM; CLU_019859_1_0_1; -.
DR   InParanoid; Q9VMX1; -.
DR   OMA; ICRECWY; -.
DR   OrthoDB; 1516717at2759; -.
DR   PhylomeDB; Q9VMX1; -.
DR   BioGRID-ORCS; 33714; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 33714; -.
DR   PRO; PR:Q9VMX1; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0031659; Expressed in testis and 26 other tissues.
DR   ExpressionAtlas; Q9VMX1; baseline and differential.
DR   Genevisible; Q9VMX1; DM.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0006839; P:mitochondrial transport; ISS:UniProtKB.
DR   GO; GO:1990535; P:neuron projection maintenance; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR022083; KBP.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46321; PTHR46321; 1.
DR   Pfam; PF12309; KBP_C; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..600
FT                   /note="KIF-binding protein"
FT                   /id="PRO_0000334520"
FT   COILED          384..434
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   600 AA;  69685 MW;  B9644F90BF6CC2BC CRC64;
     MVIPKEILSD FKELYEKANR LVEEESRNDP PTDPFRSHYK ARDVLIVLKK QLDDQLVSVQ
     ASEEDGGQDD RCYHSLLAFV CRDLGRIYIY TEEQAEGEKM LNRCLELVTP FKECPEGIIP
     FIGAINELSI VLASKEEYNK GLEILLEAEK IYEDFKASGL KPLAIQDVFN PPEEGQQSHE
     AGPKELESLY TLVSFYMAQM YGHLGEPEKS AKCCHRTLHR QLESKTYDPI DFALNTATLS
     QFYIGEKRFE EARHHLAAAT LIMAEYEVHM LEPEMSEKQR QDVSETFKHR YADVARCWAK
     YGLYLMNTSK LRLMRDEDDE DAKNLEIVLR NMRLVEAEQS RFPGLDLTAC ENRISCEYCL
     TFDDAKLVFH FVNEWLDIAK DYYKAENEAT EYSKIMQDYA EAYEHIAFFE ENPENQAKMQ
     KRRAKYLEDL LDLLDPIFYM KICRECWYGA GTAHAAVMDV RLDIIRATST PAPEDIKKVN
     QSCMKAIKHF ESYVKSYLVK PPSEEWRPNM DVEEQRHMLY AHFHIGRIYY KLISGHPLQQ
     LEHLTSCHTY YQRFDAGCQL HKEAAETLQG EIGVVREMLQ LLPLKINTIK ARLNKAGLTA