KBP_MOUSE
ID KBP_MOUSE Reviewed; 617 AA.
AC Q6ZPU9; Q3TYD0; Q5BKR5; Q7TPE0; Q80VQ5; Q8BZE2; Q8CFS7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=KIF-binding protein;
DE AltName: Full=KIF1-binding protein {ECO:0000250|UniProtKB:Q96EK5};
GN Name=Kifbp {ECO:0000250|UniProtKB:Q96EK5};
GN Synonyms=Kbp {ECO:0000250|UniProtKB:Q96EK5},
GN Kiaa1279 {ECO:0000303|PubMed:14621295},
GN Kif1bp {ECO:0000312|MGI:MGI:1919570};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Urinary bladder, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=NMRI; TISSUE=Eye, Mammary tumor, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20621975; DOI=10.1093/hmg/ddq280;
RA Alves M.M., Burzynski G., Delalande J.M., Osinga J., van der Goot A.,
RA Dolga A.M., de Graaff E., Brooks A.S., Metzger M., Eisel U.L., Shepherd I.,
RA Eggen B.J., Hofstra R.M.;
RT "KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to
RT microtubule dynamics and neuronal differentiation.";
RL Hum. Mol. Genet. 19:3642-3651(2010).
CC -!- FUNCTION: Required for neuronal development and differentiation.
CC Required for organization of axonal microtubules, and axonal outgrowth
CC and maintenance during peripheral and central nervous system
CC development. {ECO:0000269|PubMed:20621975}.
CC -!- SUBUNIT: Interacts with KIF1B. Interacts with STMN2.
CC {ECO:0000250|UniProtKB:Q96EK5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q96EK5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZPU9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZPU9-2; Sequence=VSP_015214, VSP_015215;
CC Name=3;
CC IsoId=Q6ZPU9-3; Sequence=VSP_015213;
CC -!- TISSUE SPECIFICITY: In th embryo it is expressed in cortical neurons;
CC expression increases during neuronal development.
CC {ECO:0000269|PubMed:20621975}.
CC -!- SIMILARITY: Belongs to the KIF-binding protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH90974.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAC98130.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129320; BAC98130.1; ALT_INIT; mRNA.
DR EMBL; AK035659; BAC29142.1; -; mRNA.
DR EMBL; AK158730; BAE34633.1; -; mRNA.
DR EMBL; BC038828; AAH38828.1; -; mRNA.
DR EMBL; BC046485; AAH46485.1; -; mRNA.
DR EMBL; BC055307; AAH55307.1; -; mRNA.
DR EMBL; BC090974; AAH90974.1; ALT_SEQ; mRNA.
DR CCDS; CCDS23890.1; -. [Q6ZPU9-1]
DR RefSeq; NP_082473.2; NM_028197.2. [Q6ZPU9-1]
DR AlphaFoldDB; Q6ZPU9; -.
DR SMR; Q6ZPU9; -.
DR BioGRID; 215306; 29.
DR IntAct; Q6ZPU9; 22.
DR STRING; 10090.ENSMUSP00000065160; -.
DR iPTMnet; Q6ZPU9; -.
DR PhosphoSitePlus; Q6ZPU9; -.
DR EPD; Q6ZPU9; -.
DR MaxQB; Q6ZPU9; -.
DR PaxDb; Q6ZPU9; -.
DR PeptideAtlas; Q6ZPU9; -.
DR PRIDE; Q6ZPU9; -.
DR ProteomicsDB; 301749; -. [Q6ZPU9-1]
DR ProteomicsDB; 301750; -. [Q6ZPU9-2]
DR ProteomicsDB; 301751; -. [Q6ZPU9-3]
DR Antibodypedia; 28675; 102 antibodies from 20 providers.
DR DNASU; 72320; -.
DR Ensembl; ENSMUST00000065887; ENSMUSP00000065160; ENSMUSG00000036955. [Q6ZPU9-1]
DR GeneID; 72320; -.
DR KEGG; mmu:72320; -.
DR UCSC; uc007fhk.1; mouse. [Q6ZPU9-1]
DR UCSC; uc007fhl.1; mouse. [Q6ZPU9-2]
DR UCSC; uc011xfd.1; mouse. [Q6ZPU9-3]
DR CTD; 26128; -.
DR MGI; MGI:1919570; Kifbp.
DR VEuPathDB; HostDB:ENSMUSG00000036955; -.
DR eggNOG; ENOG502QPZT; Eukaryota.
DR GeneTree; ENSGT00390000013819; -.
DR HOGENOM; CLU_019859_1_0_1; -.
DR InParanoid; Q6ZPU9; -.
DR OMA; ICRECWY; -.
DR OrthoDB; 1516717at2759; -.
DR PhylomeDB; Q6ZPU9; -.
DR TreeFam; TF324211; -.
DR BioGRID-ORCS; 72320; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Kif1bp; mouse.
DR PRO; PR:Q6ZPU9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6ZPU9; protein.
DR Bgee; ENSMUSG00000036955; Expressed in temporal lobe and 218 other tissues.
DR ExpressionAtlas; Q6ZPU9; baseline and differential.
DR Genevisible; Q6ZPU9; MM.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0019894; F:kinesin binding; ISO:MGI.
DR GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; ISS:UniProtKB.
DR GO; GO:1990535; P:neuron projection maintenance; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR022083; KBP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR46321; PTHR46321; 1.
DR Pfam; PF12309; KBP_C; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Developmental protein;
KW Differentiation; Neurogenesis; Phosphoprotein; Reference proteome.
FT CHAIN 1..617
FT /note="KIF-binding protein"
FT /id="PRO_0000050792"
FT REGION 48..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 174
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96EK5"
FT VAR_SEQ 1..317
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_015213"
FT VAR_SEQ 327..393
FT /note="DNIGELDLDKQSELRALRKKELDEEESVRKRAVQFGTGELCDAISAVEEKVR
FT YLRPLDFEEARELFL -> VCTWKWPAASVRLIIRPTMCFVVLSFTLCVCVCVCVCICR
FT FGGMYMSACGQPGFLRQSLSLVLGLGD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_015214"
FT VAR_SEQ 394..617
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_015215"
FT CONFLICT 321
FT /note="A -> V (in Ref. 3; AAH38828)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="Y -> H (in Ref. 3; AAH55307)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 617 AA; 71052 MW; 73FCED7C852DC51E CRC64;
MANAPGPEIR EKFQAALALS RVELHKNPEK EPYKSKYGAR ALLEEVRALL GPAPEDEDEP
AADDGPGDQA LGAGEPREAE GPGAQRALRL AVVEFHLGVN HIDTEELSAG EEHLVRCLSL
LRPYRLSLGC VSLYIQAQNN LGILWSEREE IETARTYLES SEALYSQYMK EIGSPPLDPT
EHFLPEEEKL TEQERSKRFE KVYTHNLYYL AQVYQHMEMF EKAAHYCHST LKRQLEHNAY
HPMEWAINAA TLSQFYINKL CFMEARHCLS AANVIFGQTG KIPATEDTPE VEGDVPELYH
QRKGEIARCW IKYCLTLMQN AQLSMQDNIG ELDLDKQSEL RALRKKELDE EESVRKRAVQ
FGTGELCDAI SAVEEKVRYL RPLDFEEARE LFLLGQHYVC EAKEFFQIDG YVTDHIEVVQ
DHSALFKVLS FFEADMERRC KMHKRRIAML EPLTVDLNPQ YYLLVSRQIQ FEIAHAYYDM
MDLKVAIADK LRDPDSHIVK KINSLNKSAL KYYQLFLDSL RDPNKVFPEH IGEDVLRPAM
LAKFRVARLY GKIITADPKK ELENLATSLE HYKFIVDYCE THPEAAQEIE VELELSKEMV
SLLPTKMERF RAKMALT
