KBP_RAT
ID KBP_RAT Reviewed; 617 AA.
AC Q4G074;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=KIF-binding protein;
DE AltName: Full=KIF1-binding protein;
GN Name=Kifbp; Synonyms=Kbp;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION.
RX PubMed=20621975; DOI=10.1093/hmg/ddq280;
RA Alves M.M., Burzynski G., Delalande J.M., Osinga J., van der Goot A.,
RA Dolga A.M., de Graaff E., Brooks A.S., Metzger M., Eisel U.L., Shepherd I.,
RA Eggen B.J., Hofstra R.M.;
RT "KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to
RT microtubule dynamics and neuronal differentiation.";
RL Hum. Mol. Genet. 19:3642-3651(2010).
CC -!- FUNCTION: Required for organization of axonal microtubules, and axonal
CC outgrowth and maintenance during peripheral and central nervous system
CC development. {ECO:0000269|PubMed:20621975}.
CC -!- SUBUNIT: Interacts with KIF1B. Interacts with STMN2.
CC {ECO:0000250|UniProtKB:Q96EK5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q96EK5}.
CC -!- SIMILARITY: Belongs to the KIF-binding protein family. {ECO:0000305}.
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DR EMBL; BC098692; AAH98692.1; -; mRNA.
DR RefSeq; NP_001026797.1; NM_001031627.1.
DR AlphaFoldDB; Q4G074; -.
DR SMR; Q4G074; -.
DR STRING; 10116.ENSRNOP00000000444; -.
DR PhosphoSitePlus; Q4G074; -.
DR jPOST; Q4G074; -.
DR PaxDb; Q4G074; -.
DR PRIDE; Q4G074; -.
DR GeneID; 606294; -.
DR KEGG; rno:606294; -.
DR UCSC; RGD:1593126; rat.
DR CTD; 26128; -.
DR RGD; 1593126; Kifbp.
DR eggNOG; ENOG502QPZT; Eukaryota.
DR InParanoid; Q4G074; -.
DR OrthoDB; 1516717at2759; -.
DR PhylomeDB; Q4G074; -.
DR PRO; PR:Q4G074; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0019894; F:kinesin binding; ISO:RGD.
DR GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; ISS:UniProtKB.
DR GO; GO:1990535; P:neuron projection maintenance; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR022083; KBP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR46321; PTHR46321; 1.
DR Pfam; PF12309; KBP_C; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW Neurogenesis; Phosphoprotein; Reference proteome.
FT CHAIN 1..617
FT /note="KIF-binding protein"
FT /id="PRO_0000334517"
FT REGION 48..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 174
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96EK5"
SQ SEQUENCE 617 AA; 71296 MW; 2D82AAEA658B6301 CRC64;
MAGAPGPEIR EKFQAALALS RVELHKNPEK EPYKSKYGAR ALLEEVRALL GPAPEDDDER
AADDGPVDQA LGAGEPRDAE GPGAQRALRL AVVEFHLGVN HIDTEELSAG EEHLVRCLSL
LRPYRLSLGC VSLFIQAQNN LGILWSEREE IETARTYLES SEALYNQYMK EIGSPPLDPT
EHFLPEEEKL TEQERSKRFE KVYTHNLYYL AQVYQHMEMF EKAAHYCHST LKRQLEHNAY
HPMEWAINAA TLSQFYINKL CFMEARHCLS AANVIFGQTG KITATEDTPE VEGDMPELYH
QRKGEIARCW IKYCLTLMQN AQLSMQDNIG ELDLDKQSEL RALRRKELDE EESVRKRAVQ
FGTGELRDAI SAVEEKVRYL RPLDFEEARE LFLLGQHYVY EAKEFFQIDG YVTDHIEVVQ
DHSALFKVLA FFEADMERRC KMHKRRIAML EPLIVDLNPQ YYQLVNRQIQ FEIAHAYYDM
MDLKVAIADK LREPDSHTVK KINSLNQSAL KYYQLFLDSL RDPNKVFPEH IGEDVLRPAM
LAKFRVARLY GKIITADPKK ELENLATSLE HYKFIVDYCE THPEAAQEIE VELELSKEMV
SLLPTKMERF RAKMALT