KBRS2_CHICK
ID KBRS2_CHICK Reviewed; 191 AA.
AC Q5ZJW6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=NF-kappa-B inhibitor-interacting Ras-like protein 2;
DE AltName: Full=I-kappa-B-interacting Ras-like protein 2;
DE Short=Kappa B-Ras protein 2;
DE Short=KappaB-Ras2;
GN Name=NKIRAS2; ORFNames=RCJMB04_15a13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Atypical Ras-like protein that acts as a potent regulator of
CC NF-kappa-B activity by preventing the degradation of NF-kappa-B
CC inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more
CC resistant to degradation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: In contrast to other members of the Ras family, the members of
CC the KappaB-Ras subfamily do not contain the conserved Gly and Gln
CC residues in positions 13 and 65, which are replaced by Ala and Leu
CC residues, respectively, and are therefore similar to the constitutively
CC active forms of oncogenic forms of Ras. This suggests that members of
CC this family are clearly different from other small GTPases proteins.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC KappaB-Ras subfamily. {ECO:0000305}.
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DR EMBL; AJ720318; CAG31977.1; -; mRNA.
DR RefSeq; NP_001006333.1; NM_001006333.1.
DR AlphaFoldDB; Q5ZJW6; -.
DR SMR; Q5ZJW6; -.
DR STRING; 9031.ENSGALP00000041419; -.
DR PaxDb; Q5ZJW6; -.
DR Ensembl; ENSGALT00000044950; ENSGALP00000041419; ENSGALG00000028971.
DR GeneID; 420032; -.
DR KEGG; gga:420032; -.
DR CTD; 28511; -.
DR VEuPathDB; HostDB:geneid_420032; -.
DR eggNOG; KOG3883; Eukaryota.
DR GeneTree; ENSGT00940000157943; -.
DR HOGENOM; CLU_041217_17_1_1; -.
DR InParanoid; Q5ZJW6; -.
DR OMA; HPPQTKS; -.
DR OrthoDB; 1382000at2759; -.
DR PhylomeDB; Q5ZJW6; -.
DR TreeFam; TF314483; -.
DR PRO; PR:Q5ZJW6; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000028971; Expressed in granulocyte and 13 other tissues.
DR ExpressionAtlas; Q5ZJW6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0032794; F:GTPase activating protein binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0032484; P:Ral protein signal transduction; IBA:GO_Central.
DR GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0043129; P:surfactant homeostasis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR042227; KBRS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46152; PTHR46152; 1.
DR Pfam; PF00071; Ras; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..191
FT /note="NF-kappa-B inhibitor-interacting Ras-like protein 2"
FT /id="PRO_0000225681"
FT REGION 1..191
FT /note="Small GTPase-like"
FT REGION 170..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 35..43
FT /note="Effector region"
FT BINDING 11..18
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 61..65
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 120..123
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 191 AA; 21503 MW; 0AAD87C7FAFB5D98 CRC64;
MGKSCKVVVC GQAAVGKTAI LEQLLYGNHV VGSEMIETQE DIYVGSIETD RGVREQVRFY
DTRGLRDGLE LPKHCFSCTD GYVLVYSTDS KESFRRVELL KKEIDKCKDK KEVTIVVLGN
KCDLQEQRRV DHDAAQHWAK GEKVKLWEVS VADRRTLIEP FIYLASKMTQ PQSKSAFPLS
RKNKGSGSVD G
