ID   KBRS2_DANRE             Reviewed;         192 AA.
AC   Q6DGL2;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=NF-kappa-B inhibitor-interacting Ras-like protein 2;
DE   AltName: Full=I-kappa-B-interacting Ras-like protein 2;
DE            Short=Kappa B-Ras protein 2;
DE            Short=KappaB-Ras2;
GN   Name=nkiras2; ORFNames=zgc:92870;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Atypical Ras-like protein that acts as a potent regulator of
CC       NF-kappa-B activity by preventing the degradation of NF-kappa-B
CC       inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more
CC       resistant to degradation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: In contrast to other members of the Ras family, the members of
CC       the KappaB-Ras subfamily do not contain the conserved Gln residues in
CC       position and 65, which is replaced by a Leu residue, and are therefore
CC       similar to the constitutively active forms of oncogenic forms of Ras.
CC       This suggests that members of this family are clearly different from
CC       other small GTPases proteins.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       KappaB-Ras subfamily. {ECO:0000305}.
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DR   EMBL; BC076330; AAH76330.1; -; mRNA.
DR   RefSeq; NP_001003433.1; NM_001003433.1.
DR   AlphaFoldDB; Q6DGL2; -.
DR   SMR; Q6DGL2; -.
DR   STRING; 7955.ENSDARP00000068967; -.
DR   PaxDb; Q6DGL2; -.
DR   GeneID; 445039; -.
DR   KEGG; dre:445039; -.
DR   CTD; 28511; -.
DR   ZFIN; ZDB-GENE-040801-166; nkiras2.
DR   eggNOG; KOG3883; Eukaryota.
DR   InParanoid; Q6DGL2; -.
DR   OrthoDB; 1382000at2759; -.
DR   PhylomeDB; Q6DGL2; -.
DR   Reactome; R-DRE-1810476; RIP-mediated NFkB activation via ZBP1.
DR   Reactome; R-DRE-445989; TAK1-dependent IKK and NF-kappa-B activation.
DR   Reactome; R-DRE-933542; TRAF6 mediated NF-kB activation.
DR   PRO; PR:Q6DGL2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0032794; F:GTPase activating protein binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0032484; P:Ral protein signal transduction; IBA:GO_Central.
DR   GO; GO:0043129; P:surfactant homeostasis; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR042227; KBRS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR46152; PTHR46152; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..192
FT                   /note="NF-kappa-B inhibitor-interacting Ras-like protein 2"
FT                   /id="PRO_0000225682"
FT   REGION          169..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           35..43
FT                   /note="Effector region"
FT   BINDING         11..18
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         61..65
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         120..123
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   192 AA;  21913 MW;  3D71F35269562DD7 CRC64;
     MGKSCKVVVC GQGSVGKTAV LEQLLYANHV VGSETMETLE DIYIGSVETD RGTREQVRFY
     DTRGLRDGQE FPRHYFTFAD GFVLVYSIDS RESFKRVEAL KKEIDRCRDK KEVTIVVVGN
     KLDLQDQRRV DSSAAQQWAR QEKVRLWEIS VTDRRTLIEP FVHLASKMTQ PQSKSTFPLS
     RNKNKTSGSL DS