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KBTB1_CAMPS
ID   KBTB1_CAMPS             Reviewed;         564 AA.
AC   Q8QQ16;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 1;
GN   Name=KBTB1; OrderedLocusNames=CMP172R;
OS   Camelpox virus (strain CMS).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203172;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11907336; DOI=10.1099/0022-1317-83-4-855;
RA   Gubser C., Smith G.L.;
RT   "The sequence of camelpox virus shows it is most closely related to variola
RT   virus, the cause of smallpox.";
RL   J. Gen. Virol. 83:855-872(2002).
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
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DR   EMBL; AY009089; AAG37674.1; -; Genomic_DNA.
DR   SMR; Q8QQ16; -.
DR   Proteomes; UP000107153; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR024182; Vaccinia_A55R.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF003716; VAC_F3L; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..564
FT                   /note="Kelch repeat and BTB domain-containing protein 1"
FT                   /id="PRO_0000396134"
FT   DOMAIN          21..88
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          123..219
FT                   /note="BACK"
FT   REPEAT          252..297
FT                   /note="Kelch 1"
FT   REPEAT          298..346
FT                   /note="Kelch 2"
FT   REPEAT          347..395
FT                   /note="Kelch 3"
FT   REPEAT          397..441
FT                   /note="Kelch 4"
FT   REPEAT          442..492
FT                   /note="Kelch 5"
FT   REPEAT          494..539
FT                   /note="Kelch 6"
SQ   SEQUENCE   564 AA;  64732 MW;  3906AF06A9E55E36 CRC64;
     MNNSSELIAV INGFRNSGRF CDIDIVINDE RINAHRLILS GASEYFSILF SSDFIDSNKY
     EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDI VKYILSTADF LQIGSAITEC ENYILKNLCS
     RNCIDFYIYA DKYNNKKIET ASFNTILLNI LRLINDENFK YLTEESMIKF LSDDMLNIKN
     EDFAPLILIK WLESTQQPCT VELLRCLRIS LLSPQVIKSL YSHRLVGSIY ECITFLNNIS
     FLDESFPRYH SIELISIGIS NSHDKISINC YNRKKNTWDI ISSRRYRCSF AVAVLDNIIY
     MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GVADDEYIYC IGGIRDQDSS
     LISSIDRWKP SKPYWQTYAK IREPKCDMGV AMLNGLIYVI GGVVKGDTCT DTLESLSQDG
     WMMHQRLPIK MSNMSTIVHA GKIYISGGYN NSSVVNGISN LVLSYNPIYD EWTKLSSLNI
     PRINPALWSV HNKLYVGGGI SDDIQTNTSE TYDKEKDCWT LDNGHMLPRN YIMYKCEPIK
     HKYPLEKTQY TNDFLKYLES FIGS
 
 
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