ID   KBTB1_CWPXB             Reviewed;         563 AA.
AC   Q8QMQ2;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   29-SEP-2021, entry version 78.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 1;
GN   Name=KBTB1; OrderedLocusNames=CPXV193;
OS   Cowpox virus (strain Brighton Red) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265872;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brighton Red;
RA   Dietrich F.S., Ray C.A., Sharma D.A., Allen A., Pickup D.J.;
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
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DR   EMBL; AF482758; AAM13632.1; -; Genomic_DNA.
DR   RefSeq; NP_619974.1; NC_003663.2.
DR   SMR; Q8QMQ2; -.
DR   GeneID; 1486072; -.
DR   KEGG; vg:1486072; -.
DR   Proteomes; UP000152733; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR024182; Vaccinia_A55R.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF003716; VAC_F3L; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..563
FT                   /note="Kelch repeat and BTB domain-containing protein 1"
FT                   /id="PRO_0000396135"
FT   DOMAIN          21..88
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          123..219
FT                   /note="BACK"
FT   REPEAT          252..297
FT                   /note="Kelch 1"
FT   REPEAT          298..346
FT                   /note="Kelch 2"
FT   REPEAT          347..395
FT                   /note="Kelch 3"
FT   REPEAT          397..441
FT                   /note="Kelch 4"
FT   REPEAT          442..492
FT                   /note="Kelch 5"
FT   REPEAT          494..538
FT                   /note="Kelch 6"
SQ   SEQUENCE   563 AA;  64594 MW;  F91809A70189CB80 CRC64;
     MHNSSELIAV INGFRNSGRF CDINIVINDE RINAHRLMLS GASEYFSILF SSDFIDSNDY
     EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF LQIGSAITEC EKYILKNLCS
     RNCIDFYIYA DKYNNKKIES ASFNTILRNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
     EDFAPLILIK WLESTQQPCT VELLRCLRIS LLSPQVIKSL YSHRLVSSIY ECITFLNNIA
     FLDESFPRYH SIELISIGIS NSHDKISINC YNRKKNTWEM ISSRRYRCSF AVAVLDNIIY
     MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GVADDEYIYC IGGIRDQDSS
     LISSIDRWKP SKPYWQTYAK MREPKCDMGV AMLNGLIYVI GGIVKGDTCT DALESLSEDG
     WMKHQRLPIK MSNMSTIVHA GKIYISGGYN NSSAVNGPSN LVLSYNPIYD EWTKLSSLNI
     PRINPALWSA HNKLYVGGGI SNDQTTTSET YDKEKDCWTL DNGHVLPRNY IMYKCEPIKH
     KYPLEKIQYT NDFLKCLESF IDS