ID   KBTB1_CWPXG             Reviewed;         564 AA.
AC   O72736;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   02-JUN-2021, entry version 79.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 1;
GN   Name=KBTB1; OrderedLocusNames=A57R;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Miheev M.V.,
RA   Ryazankina O.I., Petrov N.A., Gutorov V.V., Kotwal G.J., Sandakhchiev L.S.;
RT   "Structure-function and organization of cowpox virus strain GRI-90 complete
RT   genome.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X94355; CAD90724.1; -; Genomic_DNA.
DR   SMR; O72736; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR024182; Vaccinia_A55R.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF003716; VAC_F3L; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..564
FT                   /note="Kelch repeat and BTB domain-containing protein 1"
FT                   /id="PRO_0000396136"
FT   DOMAIN          21..88
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          123..219
FT                   /note="BACK"
FT   REPEAT          252..297
FT                   /note="Kelch 1"
FT   REPEAT          298..346
FT                   /note="Kelch 2"
FT   REPEAT          347..395
FT                   /note="Kelch 3"
FT   REPEAT          397..441
FT                   /note="Kelch 4"
FT   REPEAT          442..492
FT                   /note="Kelch 5"
FT   REPEAT          494..539
FT                   /note="Kelch 6"
SQ   SEQUENCE   564 AA;  64826 MW;  EF268497F8DC6AF4 CRC64;
     MNNSSELIAV INGFRNSGRF CDINIVINDE RINAHRLILS GASEYFSILF SNNFIDSNEY
     EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF LQIGSAITEC EKYILKNLCS
     RNCIDFYIYA DKYNNKKIES ASFNTILRNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
     EDFAPLILIK WLESTQQSCT VELLRCLRIS LLSPQVIKSL YSHQLVSSIY ECITFLNNIA
     FLDESFPRYH SIELISIGIS NSHDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
     MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC IGGIRDQDSS
     LTSSIDRWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVI GGIVKGDTCT DALESLSEDG
     WMKHQRLPIK MSNMSTIVHD GKIYISGGYN NSSVVNVISN LVLSYNPIYD EWTKLSSLNI
     PRINPALWSA HNKLYVGGGI SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK
     HKYPLEKTQY TNDFLKYLES FIGS