ID   KBTB1_HSPV              Reviewed;         564 AA.
AC   Q0GNQ5;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 1;
GN   Name=KBTB1; OrderedLocusNames=HSPV176;
OS   Horsepox virus (HSPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=397342;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MNR-76;
RX   PubMed=16940536; DOI=10.1128/jvi.00945-06;
RA   Tulman E.R., Delhon G., Afonso C.L., Lu Z., Zsak L., Sandybaev N.T.,
RA   Kerembekova U.Z., Zaitsev V.L., Kutish G.F., Rock D.L.;
RT   "Genome of horsepox virus.";
RL   J. Virol. 80:9244-9258(2006).
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
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DR   EMBL; DQ792504; ABH08286.1; -; Genomic_DNA.
DR   SMR; Q0GNQ5; -.
DR   PRIDE; Q0GNQ5; -.
DR   Proteomes; UP000111173; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR024182; Vaccinia_A55R.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   PIRSF; PIRSF003716; VAC_F3L; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..564
FT                   /note="Kelch repeat and BTB domain-containing protein 1"
FT                   /id="PRO_0000396137"
FT   DOMAIN          21..88
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          123..219
FT                   /note="BACK"
FT   REPEAT          252..297
FT                   /note="Kelch 1"
FT   REPEAT          298..346
FT                   /note="Kelch 2"
FT   REPEAT          347..395
FT                   /note="Kelch 3"
FT   REPEAT          397..441
FT                   /note="Kelch 4"
FT   REPEAT          442..492
FT                   /note="Kelch 5"
SQ   SEQUENCE   564 AA;  64721 MW;  C7941657CB1B6277 CRC64;
     MNSSSKLIAV INGFRNSGRF CDINIVINDE RINAHKLILS GASEYFSILF SNNFIDSNEY
     EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF LQIGSAITEC ENYILKNLCS
     KNCIDFYIYA DKYNNKKIES ASFNTILQNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
     EDFAPLILIK WLESTQQPCT VELLKCLRIS LLSPQVIKSL YSHRLVSSIY ECITFLNNIA
     FLDESFPRYH SIELISIGIS NSRDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
     MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC IGGIRDQDSS
     LTSSIDKWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVI GGIVKGDTCT DALESLSEDG
     WMKHQRLPIK MSNMSTIVHD GKIYISGGYN NSSVVNVISN LVLSYNSIYD EWTKLSSLNI
     PRINPALWST HNKLYVGGGI SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK
     HKYPLEKTQY TNDFLKYLES FIGS