ID   KBTB1_VACCC             Reviewed;         564 AA.
AC   P21073;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 100.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 1;
GN   Name=KBTB1; ORFNames=A55R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   COMPLETE GENOME.
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48190.1; -; Genomic_DNA.
DR   PIR; C42523; C42523.
DR   SMR; P21073; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR024182; Vaccinia_A55R.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF003716; VAC_F3L; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 5.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..564
FT                   /note="Kelch repeat and BTB domain-containing protein 1"
FT                   /id="PRO_0000119150"
FT   DOMAIN          21..88
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          252..297
FT                   /note="Kelch 1"
FT   REPEAT          298..346
FT                   /note="Kelch 2"
FT   REPEAT          347..395
FT                   /note="Kelch 3"
FT   REPEAT          397..441
FT                   /note="Kelch 4"
FT   REPEAT          442..492
FT                   /note="Kelch 5"
FT   REPEAT          494..539
FT                   /note="Kelch 6"
SQ   SEQUENCE   564 AA;  64719 MW;  DBE8ECB532DA9F71 CRC64;
     MNNSSELIAV INGFRNSGRF CDINIVINDE RINAHKLILS GASEYFSILF SNNFIDSNEY
     EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF LQIGSAITEC ENYILKNLCS
     KNCIDFYIYA DKYNNKKIES ASFNTILQNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
     EDFAPLILIK WLESTQQSCT VELLKCLRIS LLSPQVIKSL YSHRLVSSIY ECITFLNNIA
     FLDESFPRYH SIELISIGIS NSRDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
     MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC IGGIRDQDSS
     LTSSIDKWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVI GGIVKGDTCT DALESLSEDG
     WMKHQRLPIK MSNMSTIVHD GKIYISGGYN NSSVVNVISN LVLSYNPIYD EWTKLSSLNI
     PRINPALWSA HNKLYVGGGI SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK
     HKYPLEKTQY TNDFLKYLES FIGS