KBTB1_VACCW
ID KBTB1_VACCW Reviewed; 564 AA.
AC P24768; Q76ZM4;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 29-SEP-2021, entry version 104.
DE RecName: Full=Kelch repeat and BTB domain-containing protein A55;
GN Name=KBTB1; OrderedLocusNames=VACWR180; ORFNames=A55R;
OS Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS WR)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10254;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA Smith G.L., Chan Y.S., Howard S.T.;
RT "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT right inverted terminal repeat.";
RL J. Gen. Virol. 72:1349-1376(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1846491; DOI=10.1016/0042-6822(91)90077-o;
RA Howard S.T., Chan Y.S., Smith G.L.;
RT "Vaccinia virus homologues of the Shope fibroma virus inverted terminal
RT repeat proteins and a discontinuous ORF related to the tumor necrosis
RT factor receptor family.";
RL Virology 180:633-647(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA Wohlhueter R.;
RT "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT redundancy and an error rate of 0.16/10kb.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC ubiquitin-protein ligases which mediate the ubiquitination and
CC subsequent proteasomal degradation of host target proteins.
CC -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC while the Kelch repeat domains supposely serve to recruit the cellular
CC substrates. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviruses A55 protein family.
CC {ECO:0000305}.
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DR EMBL; D11079; BAA01828.1; -; Genomic_DNA.
DR EMBL; M58054; AAA48340.1; -; Genomic_DNA.
DR EMBL; AY243312; AAO89459.1; -; Genomic_DNA.
DR PIR; JQ1792; JQ1792.
DR RefSeq; YP_233062.1; NC_006998.1.
DR PDB; 6I2M; X-ray; 2.30 A; A=1-250.
DR PDBsum; 6I2M; -.
DR SMR; P24768; -.
DR BioGRID; 3509005; 2.
DR DIP; DIP-2655N; -.
DR DNASU; 3707651; -.
DR GeneID; 3707651; -.
DR KEGG; vg:3707651; -.
DR Proteomes; UP000000344; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR024182; Vaccinia_A55R.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR PIRSF; PIRSF003716; VAC_F3L; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Early protein; Host cytoplasm; Host-virus interaction;
KW Kelch repeat; Modulation of host E3 ubiquitin ligases by virus;
KW Modulation of host ubiquitin pathway by virus; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..564
FT /note="Kelch repeat and BTB domain-containing protein A55"
FT /id="PRO_0000119151"
FT DOMAIN 21..88
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 252..297
FT /note="Kelch 1"
FT REPEAT 298..346
FT /note="Kelch 2"
FT REPEAT 347..395
FT /note="Kelch 3"
FT REPEAT 397..441
FT /note="Kelch 4"
FT REPEAT 442..492
FT /note="Kelch 5"
FT REPEAT 494..539
FT /note="Kelch 6"
FT HELIX 4..17
FT /evidence="ECO:0007829|PDB:6I2M"
FT TURN 18..20
FT /evidence="ECO:0007829|PDB:6I2M"
FT STRAND 23..27
FT /evidence="ECO:0007829|PDB:6I2M"
FT STRAND 30..34
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 36..42
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 44..49
FT /evidence="ECO:0007829|PDB:6I2M"
FT STRAND 51..54
FT /evidence="ECO:0007829|PDB:6I2M"
FT STRAND 60..63
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 69..79
FT /evidence="ECO:0007829|PDB:6I2M"
FT TURN 88..90
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 91..101
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 104..116
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 120..132
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 136..147
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 150..153
FT /evidence="ECO:0007829|PDB:6I2M"
FT STRAND 154..156
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 157..161
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 164..171
FT /evidence="ECO:0007829|PDB:6I2M"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:6I2M"
FT HELIX 184..195
FT /evidence="ECO:0007829|PDB:6I2M"
SQ SEQUENCE 564 AA; 64691 MW; FDAC2001F6EF7507 CRC64;
MNNSSELIAV INGFRNSGRF CDISIVINDE RINAHKLILS GASEYFSILF SNNFIDSNEY
EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF LQIGSAITEC ENYILKNLCS
KNCIDFYIYA DKYNNKKIES ASFNTILQNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
EDFAPLILIK WLESTQQSCT VELLRCLRIS LLSPQVIKSL YSHQLVSSIY ECITFLNNIA
FLDESFPRYH SIELISIGIS NSHDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC IGGIRDQDSS
LTSSIDKWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVM GGIVKGDTCT DALESLSEDG
WMKHQRLPIK MSNMSTIVHD GKIYISGGYN NSSVVNVISN LVLSYNPIYD EWTKLSSLNI
PRINPALWSA HNKLYVGGGI SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK
HKYPLEKTQY TNDFLKYLES FIGS
