ID   KBTB2_CWPXB             Reviewed;         557 AA.
AC   Q8QMN3;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   29-SEP-2021, entry version 79.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 2;
GN   Name=KBTB2; OrderedLocusNames=CPXV215;
OS   Cowpox virus (strain Brighton Red) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265872;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brighton Red;
RA   Dietrich F.S., Ray C.A., Sharma D.A., Allen A., Pickup D.J.;
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
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DR   EMBL; AF482758; AAM13653.1; -; Genomic_DNA.
DR   RefSeq; NP_619995.1; NC_003663.2.
DR   SMR; Q8QMN3; -.
DR   GeneID; 1486094; -.
DR   KEGG; vg:1486094; -.
DR   Proteomes; UP000152733; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..557
FT                   /note="Kelch repeat and BTB domain-containing protein 2"
FT                   /id="PRO_0000396131"
FT   DOMAIN          26..95
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          143..223
FT                   /note="BACK"
FT   REPEAT          305..352
FT                   /note="Kelch 1"
FT   REPEAT          353..399
FT                   /note="Kelch 2"
FT   REPEAT          415..464
FT                   /note="Kelch 3"
SQ   SEQUENCE   557 AA;  64882 MW;  1BD80F1A588A1ABF CRC64;
     MDIENDIRNR RIIRNISNLL DDDILCDVII TIRDGEEIKA HKTILAAGST YFKTMFTTPM
     IARDLVTRVN LQMFDKDAVK NIVQYLYNRH ISSMNVIDVL KCADYLLIDD LVADCESYIK
     DYTNHDTCIC MYHKLYEMIH IPIVKYIKRM LMSNIPTLIT TDAFKKTVFE ILFDIISTND
     NVYLYREGYK VTILLKWLEH NYITEEQLLC ILSCIDIQNL DKKSRLLLYS NKTINMYPSC
     IQFLIDNKQN RNIIPRQLCL VCHDTKYNVC NPCILVYNIN TMEYSVISTI PNHIINYASA
     IVDNEIIIAG GYNFNNPSLN KVYKINIENK IHVELPPMIK NRCRFSLAVI DDTIYAIGGQ
     NGTNVERTIE CYTMGDDKWK LLPDMPIALS SYGMCVLDQY IYIIGGSTLY IDYTSVHAVN
     SIDMEEDTDT SNKVIRYDTV NNIWETLPNF WTGTIKPGVV SHEDDIYVVC DIKDEKNVKT
     CIFRYNTNTY NGWELVTTTE SRLSALHTIL HDNTIMMLHC YESYMLQDTF NVYTREWNHT
     CHQHSNSYIM HNILPIY