ID   KBTB2_CWPXG             Reviewed;         557 AA.
AC   O72756;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 2;
GN   Name=KBTB2; OrderedLocusNames=B19R;
OS   Cowpox virus (strain GRI-90 / Grishak) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265871;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Shchelkunov S.N., Safronov P.F., Totmenin A.V., Miheev M.V.,
RA   Ryazankina O.I., Petrov N.A., Gutorov V.V., Kotwal G.J., Sandakhchiev L.S.;
RT   "Structure-function and organization of cowpox virus strain GRI-90 complete
RT   genome.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC       ubiquitin-protein ligases which mediate the ubiquitination and
CC       subsequent proteasomal degradation of host target proteins.
CC   -!- SUBUNIT: Interacts (via BTB domain) with host CUL3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The BTB domain is responsible for the interaction with CUL3
CC       while the Kelch repeat domains supposely serve to recruit the cellular
CC       substrates. {ECO:0000250}.
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DR   EMBL; X94355; CAD90745.1; -; Genomic_DNA.
DR   SMR; O72756; -.
DR   PRIDE; O72756; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction; Kelch repeat;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..557
FT                   /note="Kelch repeat and BTB domain-containing protein 2"
FT                   /id="PRO_0000396132"
FT   DOMAIN          26..95
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          133..223
FT                   /note="BACK"
FT   REPEAT          305..352
FT                   /note="Kelch 1"
FT   REPEAT          353..399
FT                   /note="Kelch 2"
FT   REPEAT          401..464
FT                   /note="Kelch 3"
SQ   SEQUENCE   557 AA;  64913 MW;  FC7CD74C0B7553D7 CRC64;
     MDIENDIRNR RIIRNISNLL DDDILCDVII TIGDGEEIKA HKTILAAGST YFKTMFTTPM
     IARDLVTRVN LQMFDKDAVK NIVQYLYNRH ISSMNVIDVL KCADYLLIDD LVADCESYIK
     DYINHDTCIY MYHKLYEMVH IPIVKYIKRM LMSNIPTLIT TDAFKKTVFE ILFDIISTND
     NVYLYREGYK VTILLKWLEY NHITEEQLLC ILSCIDIQNL DKKSRLLLYS NKTINMYPSC
     IQFLLDNKQN RNIIPRQLCL ACHDTNYNVC NPCILVYNIN TMEYSVISTI PNHIINYASA
     IVDNEIIIAG GYNFNNPSLN KVYKINIENK IHVELPPMIK NRCRFSLAVI DDTIYAIGGQ
     NGTNVERTIE CYTLGDDKWK MLPDMPIALS SYGMCVLDQY IYIIGGRTQH IDYTSVHTVN
     SIDMEEDTNI SNKVIRYDTV NNIWETLPNF WTGTINPGVV SHKDDIYVVC DIKDEKNVKT
     CIFRYNTNTY NGWELVTTTE SRLSALHTIL HDNTIMMLHC YESYMLQDTF NVYTREWNHM
     CHQHSNSYIM HNILPIY