ID   KBTB2_PONAB             Reviewed;         623 AA.
AC   Q5RDY3;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 2;
GN   Name=KBTBD2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CR857759; CAH90024.1; -; mRNA.
DR   RefSeq; NP_001124963.1; NM_001131491.1.
DR   AlphaFoldDB; Q5RDY3; -.
DR   SMR; Q5RDY3; -.
DR   STRING; 9601.ENSPPYP00000019790; -.
DR   GeneID; 100171836; -.
DR   KEGG; pon:100171836; -.
DR   CTD; 25948; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q5RDY3; -.
DR   Proteomes; UP000001595; Unplaced.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR030586; KBTBD2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF192; PTHR24412:SF192; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..623
FT                   /note="Kelch repeat and BTB domain-containing protein 2"
FT                   /id="PRO_0000261590"
FT   DOMAIN          31..98
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          317..380
FT                   /note="Kelch 1"
FT   REPEAT          381..429
FT                   /note="Kelch 2"
FT   REPEAT          431..469
FT                   /note="Kelch 3"
FT   REPEAT          470..529
FT                   /note="Kelch 4"
FT   REPEAT          535..581
FT                   /note="Kelch 5"
FT   MOD_RES         300
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY47"
SQ   SEQUENCE   623 AA;  71291 MW;  AC9A7AD3FA409AAB CRC64;
     MSTQDERQIN TEYAVSLLEQ LKQFYEQQLF TDIVLIVEGT EFPCHKMVLA TCSSYFRAMF
     MSGLSESKQT HVHLRNVDAA TLQIIITYAY TGNLAMNDST VEQLYETACF LQVEDVLQRC
     REYLIKKINA ENCVRLLSFA DLFSCEELKQ SAKRMVEHKF TAVYHQDAFM QLSHDLLIDI
     LSSDNLNVEK EETVREAAML WLEYNTESRS QYLSSVLSQI RIDALSEVTQ RAWFQGLPPN
     DKSVVAQGLY KSMPKFFKPR LGMTKEEMMI FIEASSENPC SLYSSVCYSP QAEKVYKLCS
     PPADLHKVGT VVTPDNDIYI AGGQVPLKNT KTNHSKTSKL QTAFRTVNCF YWFDAQQNTW
     FPKTPMLFVR IKPSLVCCEG HIYAIGGDSV GGELNRRTVE RYDTEKDEWT MVSPLPCAWQ
     WSAAVVVHDC IYVMTLNLMY CYFPRSDSWV EMAMRQTSRS FASAAAFGDK IFYIGGLHIA
     TNSGIRLPSG TVDGSSVTVE IYDVNKNEWK MAANIPAKRY SDPCVRAVVI SNSLCVFMRE
     THLNERAKYV TYQYDLELDR WSLRQHISER VLWDLGRDFR CTVGKLYPSC LEESPWKPPT
     YLFSTDGTEE FELDGEMVAL PPV