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KBTB3_MOUSE
ID   KBTB3_MOUSE             Reviewed;         607 AA.
AC   Q8BHI4; Q8BNJ8;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 3 {ECO:0000305};
DE   AltName: Full=BTB and kelch domain-containing protein 3;
GN   Name=Kbtbd3 {ECO:0000312|MGI:MGI:1916399}; Synonyms=Bklhd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Diencephalon, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK034334; BAC28678.1; -; mRNA.
DR   EMBL; AK078744; BAC37374.1; -; mRNA.
DR   EMBL; AK083497; BAC38935.1; -; mRNA.
DR   EMBL; BC027392; AAH27392.1; -; mRNA.
DR   CCDS; CCDS22795.1; -.
DR   RefSeq; NP_001158046.1; NM_001164574.1.
DR   RefSeq; NP_081238.2; NM_026962.3.
DR   RefSeq; XP_011240669.1; XM_011242367.1.
DR   RefSeq; XP_011240670.1; XM_011242368.1.
DR   AlphaFoldDB; Q8BHI4; -.
DR   SMR; Q8BHI4; -.
DR   STRING; 10090.ENSMUSP00000050183; -.
DR   PhosphoSitePlus; Q8BHI4; -.
DR   PaxDb; Q8BHI4; -.
DR   PRIDE; Q8BHI4; -.
DR   ProteomicsDB; 263576; -.
DR   Antibodypedia; 54357; 92 antibodies from 15 providers.
DR   DNASU; 69149; -.
DR   Ensembl; ENSMUST00000049648; ENSMUSP00000050183; ENSMUSG00000025893.
DR   Ensembl; ENSMUST00000212221; ENSMUSP00000148445; ENSMUSG00000025893.
DR   GeneID; 69149; -.
DR   KEGG; mmu:69149; -.
DR   UCSC; uc009obj.2; mouse.
DR   CTD; 143879; -.
DR   MGI; MGI:1916399; Kbtbd3.
DR   VEuPathDB; HostDB:ENSMUSG00000025893; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000158415; -.
DR   HOGENOM; CLU_004253_14_6_1; -.
DR   InParanoid; Q8BHI4; -.
DR   OMA; KGKCCRK; -.
DR   OrthoDB; 254234at2759; -.
DR   PhylomeDB; Q8BHI4; -.
DR   TreeFam; TF329218; -.
DR   BioGRID-ORCS; 69149; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Kbtbd3; mouse.
DR   PRO; PR:Q8BHI4; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BHI4; protein.
DR   Bgee; ENSMUSG00000025893; Expressed in interventricular septum and 122 other tissues.
DR   Genevisible; Q8BHI4; MM.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR030589; KBTBD3.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF418; PTHR24412:SF418; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..607
FT                   /note="Kelch repeat and BTB domain-containing protein 3"
FT                   /id="PRO_0000119079"
FT   DOMAIN          48..115
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          150..250
FT                   /note="BACK"
FT                   /evidence="ECO:0000255"
FT   REPEAT          291..337
FT                   /note="Kelch 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          339..390
FT                   /note="Kelch 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          400..450
FT                   /note="Kelch 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          452..502
FT                   /note="Kelch 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          548..595
FT                   /note="Kelch 5"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        440
FT                   /note="I -> M (in Ref. 1; BAC38935)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   607 AA;  69551 MW;  1AE2DAE6875244CD CRC64;
     MDNSYNLNEQ SSWNGISSEK KKNYLASEDH GQKILSVLQS FREQNVFYDF KIIMKEEIIP
     CHRCVLAACS DFFRAMFEVN MKERDDGSVT ITNLSSKAVK AFLDYAYTGK TRITDDNVEM
     FFQLSSFLQV SFLSKACSDF LIKSISLVNC LHLLSLSDSY GSAQLFSHTL YFVQHHFHLL
     YKSSDFLEMN FGVLQKCLES DELNVPEEEM VLKAVLTWIK YNLESRQKHL PHLITKVRLH
     QLSEDTLQDY LLNEEYLLKS TNCFDIIVDA IKCVQGSSGL FPDARPSTTE KYIFIHKTEE
     NGENQYTFCY NIKTDSWKIL PQSHLIDLPG SSLSSYGEKI FLTGGCKGKC CRRIRLHIAQ
     SYHDATDQTW CYCPAKNEFF CVSAMKTPRT MHTSVMALNR LFVIGGKTRG SQDIKSLLDV
     ESYNPLSREW TSVSPLPRGI YYPEASACQN IIYVLGSEVE IADAFNPSLD CFFKYNATTD
     QWSELVAEFG QFFHATLIKA VPVNCTLYIC DLSTYKVYSF CPDTCVWKGE GSFECAGFNA
     GAIGIEDKIY ILGGDYAPDE ITDEVQVYHS SRSEWEEVSP MPRALTEFYC QVIQFNKYRD
     PWYSNHF
 
 
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