ID   KBTB3_PONAB             Reviewed;         612 AA.
AC   Q5R663;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 3.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 3 {ECO:0000305};
GN   Name=KBTBD3 {ECO:0000250|UniProtKB:Q8NAB2};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; CR860633; CAH92753.1; -; mRNA.
DR   RefSeq; NP_001126605.1; NM_001133133.1.
DR   AlphaFoldDB; Q5R663; -.
DR   SMR; Q5R663; -.
DR   STRING; 9601.ENSPPYP00000004383; -.
DR   GeneID; 100173602; -.
DR   KEGG; pon:100173602; -.
DR   CTD; 143879; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q5R663; -.
DR   Proteomes; UP000001595; Unplaced.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR030589; KBTBD3.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF418; PTHR24412:SF418; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..612
FT                   /note="Kelch repeat and BTB domain-containing protein 3"
FT                   /id="PRO_0000286394"
FT   DOMAIN          52..119
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          150..250
FT                   /note="BACK"
FT                   /evidence="ECO:0000255"
FT   REPEAT          291..337
FT                   /note="Kelch 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          339..390
FT                   /note="Kelch 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          400..450
FT                   /note="Kelch 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          452..502
FT                   /note="Kelch 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          548..595
FT                   /note="Kelch 5"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   612 AA;  69793 MW;  8ED790EE668196D5 CRC64;
     MELAMDNSYA FNQRSTCNGI PSEKKNNFLV SEDHGQKILS VLQNFREQNV FYDFKIIMKD
     EIIPCHRCVL AACSDFFRAM FEVNMKERDD GSVTITNLSS KAVKAFLDYA YTGKTKITDD
     NVEMFFQLSS FLQVSFLSKA CSDFLIKSIN LVNCLQLLSI SDSYGSTSLF DHALHFVQHH
     FSLLFKSGDF LEMNFGVLQK CLESDELNVP EEEMVLKVVL SWTKHNLESR QKYLPHLIEK
     VRLHQLSEET LQDCLFNEES LLKSTNCFDI IMDAIKCVKG SGGLFPDARP STTEKYIFIH
     KTEENGENQY TFCYNIKSDS WKILPQSHLI DLPGSSLSSY GEKIFLTGGC KGKCCRTIRL
     HIAESYHDAT DQTWCYCPVK NDFFLVSTMK TPRTMHTSVM ALDRLFVIGG KTRGSRDIKS
     LLDVESYNPL SKEWISVSPL PRGIYYPEAS TCQNVIYVLG SEVEITDAFN PSLDCFFKYN
     AATDQWSELV AEFGQFFHAT LIKAVPVNCT LYICDLSTYK VYSFCPDTCV WKGEGSFECA
     GFNAGAIGIE DKIYILGGDY APDEITDEVQ VYHSNRSEWE EVSPMPRALT EFYCQVIQFN
     KYRDPWFSNL CA