ID   KBTB4_MACFA             Reviewed;         543 AA.
AC   Q9N010;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 4;
GN   Name=KBTBD4; ORFNames=QccE-13608;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-26 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; AB046637; BAB03555.1; -; mRNA.
DR   AlphaFoldDB; Q9N010; -.
DR   BMRB; Q9N010; -.
DR   SMR; Q9N010; -.
DR   STRING; 9541.XP_005577981.1; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   CDD; cd18481; BACK_KBTBD4; 1.
DR   CDD; cd18272; BTB_POZ_KBTBD4; 1.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR042884; KBTBD4.
DR   InterPro; IPR042950; KBTBD4_BACK.
DR   InterPro; IPR042949; KBTBD4_BTB_POZ.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR47195; PTHR47195; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..543
FT                   /note="Kelch repeat and BTB domain-containing protein 4"
FT                   /id="PRO_0000119081"
FT   DOMAIN          70..137
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          172..264
FT                   /note="BACK"
FT   REPEAT          311..353
FT                   /note="Kelch 1"
FT   REPEAT          356..403
FT                   /note="Kelch 2"
FT   REPEAT          405..455
FT                   /note="Kelch 3"
SQ   SEQUENCE   543 AA;  61054 MW;  0B57F2243254E1EF CRC64;
     MAVNSASYSR WCCFADSWQR EKLASMESPE EPGASMDENY FVNYTFKDRS HSGRVAQGTM
     KLCLEEELFA DVTISVEGRE FQLHRLVLSA QSCFFRSMFT SNLKEAHNRV IVLQDVSESV
     FQLLVDYIYH GTVKLRAEEL QEIYEVSDMY QLTSLFEECS RFLARTVQVG NCLQVMWLAD
     RHSDPELYTA AKHCAKTHLA QLQNTEEFLH LPHHLLTDII SDGVPCSQNP TEAIEAWINF
     NKEEREAFAE SLRTSLKEIG ENVHIYLIGK ESSRTHSLAV SLHCAEDDSI SVSGQNSLCH
     QITAACKHGG DLYVVGGSIP RRMWKCNNAT VDWEWCAPLP RDRLRHTLVS VPGKDAIYSL
     GGKTLQDTLS NAVIYYRVGD NVWTETTQLE VAVSGAAGAN LNGIIYLLGG EENDLDFFTK
     PSRLIQCFDT ETDKCHVKPY VLPFAGHMHA AVHKDLVFIV AEGDSLVCYN PLLDSFTRLC
     LPEAWSSAPS LWKIASRNGS IYVFRDRYKK GDANTYKLDP ATSAVTVTRG IKVLLTNLQF
     VLA