KBTB4_MOUSE
ID KBTB4_MOUSE Reviewed; 534 AA.
AC Q8R179; A2AFW3; Q9CQX1;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Kelch repeat and BTB domain-containing protein 4;
DE AltName: Full=BTB and kelch domain-containing protein 4;
GN Name=Kbtbd4; Synonyms=Bklhd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryonic liver, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R179-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R179-2; Sequence=VSP_010221;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK010998; BAB27317.1; -; mRNA.
DR EMBL; AK014373; BAB29305.1; -; mRNA.
DR EMBL; AL672241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025103; AAH25103.1; -; mRNA.
DR CCDS; CCDS16419.1; -. [Q8R179-2]
DR CCDS; CCDS79820.1; -. [Q8R179-1]
DR RefSeq; NP_001298045.1; NM_001311116.1. [Q8R179-1]
DR RefSeq; NP_080267.1; NM_025991.3. [Q8R179-2]
DR RefSeq; XP_017174704.1; XM_017319215.1.
DR AlphaFoldDB; Q8R179; -.
DR BMRB; Q8R179; -.
DR SMR; Q8R179; -.
DR BioGRID; 211968; 4.
DR STRING; 10090.ENSMUSP00000088179; -.
DR iPTMnet; Q8R179; -.
DR PhosphoSitePlus; Q8R179; -.
DR EPD; Q8R179; -.
DR MaxQB; Q8R179; -.
DR PaxDb; Q8R179; -.
DR PRIDE; Q8R179; -.
DR ProteomicsDB; 263577; -. [Q8R179-1]
DR ProteomicsDB; 263578; -. [Q8R179-2]
DR Antibodypedia; 48313; 93 antibodies from 13 providers.
DR DNASU; 67136; -.
DR Ensembl; ENSMUST00000090682; ENSMUSP00000088179; ENSMUSG00000005505. [Q8R179-2]
DR Ensembl; ENSMUST00000111464; ENSMUSP00000107089; ENSMUSG00000005505. [Q8R179-1]
DR GeneID; 67136; -.
DR KEGG; mmu:67136; -.
DR UCSC; uc008kts.1; mouse. [Q8R179-1]
DR CTD; 55709; -.
DR MGI; MGI:1914386; Kbtbd4.
DR VEuPathDB; HostDB:ENSMUSG00000005505; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158775; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q8R179; -.
DR OMA; RDNMWTE; -.
DR OrthoDB; 412256at2759; -.
DR PhylomeDB; Q8R179; -.
DR TreeFam; TF330249; -.
DR BioGRID-ORCS; 67136; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Kbtbd4; mouse.
DR PRO; PR:Q8R179; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8R179; protein.
DR Bgee; ENSMUSG00000005505; Expressed in cerebral cortex ventricular layer and 89 other tissues.
DR Genevisible; Q8R179; MM.
DR CDD; cd18481; BACK_KBTBD4; 1.
DR CDD; cd18272; BTB_POZ_KBTBD4; 1.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR042884; KBTBD4.
DR InterPro; IPR042950; KBTBD4_BACK.
DR InterPro; IPR042949; KBTBD4_BTB_POZ.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR47195; PTHR47195; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..534
FT /note="Kelch repeat and BTB domain-containing protein 4"
FT /id="PRO_0000119082"
FT DOMAIN 61..128
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 163..255
FT /note="BACK"
FT REPEAT 302..344
FT /note="Kelch 1"
FT REPEAT 347..394
FT /note="Kelch 2"
FT REPEAT 396..446
FT /note="Kelch 3"
FT VAR_SEQ 1..16
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010221"
SQ SEQUENCE 534 AA; 59857 MW; 6054F55984DB1EBE CRC64;
MKGGIADSWQ REKLATMESP EEPGASMDEN YFVNYTFKDR SHSGRVAQGI MKLCLEEELF
ADVTISVEGR EFQLHRLVLS AQSCFFRSMF TSNLKEAHNR VIVLQDVSES VFQLLVDYIY
HGTVKLRADE LQEIYEVSDM YQLTSLFEEC SRFLARTVQV GNCLQVMWLA DRHSDPELYT
AAKHCAKTHL AQLQSTEEFL HLPHHLLTDI ISDGVPCSQN PTEAIEAWIN FNKEEREAFA
ESLRTSLKEI GENVHIYLIG KESSRTHSLA VSLHCAEDDS ISVSGQNSLC HQITAACKHG
GDLYVVGGSI PRRMWKCNNA TVDWEWCAPL PRDRLQHTLV SVPGKDAIYS LGGKTLQDTL
SNAVIYYRVG DNVWTETTQL EVAVSGAAGA NLNGIIYLLG GEENDLDFFT KPSRLIQCFD
TETDKCHVKP YVLPFAGRMH AAVHKDLVFI VAEGDSLVCY NPLLDSFTRL CLPEAWSSAP
SLWKIASCNG SIYVFRDRYK KGDANTYKLD PATSAVTVTR GIKVLLTNLQ FVLA
