ID   KBTB4_PONAB             Reviewed;         518 AA.
AC   Q5R4S6; Q5RDZ6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 4;
GN   Name=KBTBD4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CR857744; CAH90011.1; -; mRNA.
DR   EMBL; CR861168; CAH93240.1; -; mRNA.
DR   RefSeq; NP_001126905.2; NM_001133433.1.
DR   AlphaFoldDB; Q5R4S6; -.
DR   BMRB; Q5R4S6; -.
DR   SMR; Q5R4S6; -.
DR   STRING; 9601.ENSPPYP00000003784; -.
DR   Ensembl; ENSPPYT00000060415; ENSPPYP00000038383; ENSPPYG00000003300.
DR   GeneID; 100173921; -.
DR   KEGG; pon:100173921; -.
DR   CTD; 55709; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000158775; -.
DR   InParanoid; Q5R4S6; -.
DR   OrthoDB; 412256at2759; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   CDD; cd18481; BACK_KBTBD4; 1.
DR   CDD; cd18272; BTB_POZ_KBTBD4; 1.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR042884; KBTBD4.
DR   InterPro; IPR042950; KBTBD4_BACK.
DR   InterPro; IPR042949; KBTBD4_BTB_POZ.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR47195; PTHR47195; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..518
FT                   /note="Kelch repeat and BTB domain-containing protein 4"
FT                   /id="PRO_0000260302"
FT   DOMAIN          45..112
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          147..239
FT                   /note="BACK"
FT   REPEAT          239..285
FT                   /note="Kelch 1"
FT   REPEAT          286..328
FT                   /note="Kelch 2"
FT   REPEAT          331..378
FT                   /note="Kelch 3"
FT   REPEAT          380..430
FT                   /note="Kelch 4"
FT   REPEAT          432..481
FT                   /note="Kelch 5"
FT   CONFLICT        229
FT                   /note="T -> A (in Ref. 1; CAH90011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        243
FT                   /note="I -> S (in Ref. 1; CAH90011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        272
FT                   /note="S -> I (in Ref. 1; CAH90011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        386
FT                   /note="E -> GGG (in Ref. 1; CAH90011)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        430
FT                   /note="D -> G (in Ref. 1; CAH90011)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   518 AA;  58125 MW;  145549B3C77A1AFF CRC64;
     MESPEEPGAS MDENYFVNYT FKDRSHSGRV AQGIMKLCLE EELFADVTIS VEGREFQLHR
     LVLSAQSCFF RSMFTSNLKE AHNRVIVLQD VSESVFQLLV DYIYHGTVKL RAEELQEIYE
     VSDMYQLTSL FEECSRFLAR TVQVGNCLQV MWLADRHSDP ELYTAAKHCA KTHLAQLQNT
     EEFLHLPHHL LTDIISDGVP CSQNPTEAIE AWINFNKEER EAFAESLRTS LKEIGENVHI
     YLIGKESSRT HSLAVSLHCA EDDSISVSGQ NSLCHQITAA CKHGGDLYVV GGSIPRRMWK
     CNNATVDWEW CAPLPRDRLQ HTLVSVPGKD AIYSLGGKTL QDTLSNAVIY YRVGDNVWTE
     TTQLEVAVSG AAGANLNGII YLLGGEENDL DFFTKPSRLI QCFDTETDKC HVKPYVLPFA
     GRMHAAVHKD LVFIVAEGDS LVCYNPLLDS FTRLCLPEAW SSAPSLWKIA SCNGSIYVFR
     DRYKKGDANT YKLDPATSAV TVTRGIKVLL TNLQFVLA