KBTBB_HUMAN
ID KBTBB_HUMAN Reviewed; 623 AA.
AC O94819; Q3L1I0;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Kelch repeat and BTB domain-containing protein 11;
DE AltName: Full=Chronic myelogenous leukemia-associated protein;
DE AltName: Full=Kelch domain-containing protein 7B;
GN Name=KBTBD11; Synonyms=CMLAP, KIAA0711, KLHDC7C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li M., Liu Y., Cheng J., Liu Y., Peng W., Fu S., Cong Y.;
RT "Homo sapiens chronic myelogenous leukemia associated protein.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=9872452; DOI=10.1093/dnares/5.5.277;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XI. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:277-286(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-107, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA34431.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY762229; AAW83120.1; -; mRNA.
DR EMBL; AB018254; BAA34431.2; ALT_INIT; mRNA.
DR EMBL; CH471181; EAW51487.1; -; Genomic_DNA.
DR CCDS; CCDS34795.1; -.
DR RefSeq; NP_055682.1; NM_014867.2.
DR RefSeq; XP_011533073.1; XM_011534771.2.
DR RefSeq; XP_011533074.1; XM_011534772.2.
DR RefSeq; XP_016869603.1; XM_017014114.1.
DR RefSeq; XP_016869604.1; XM_017014115.1.
DR RefSeq; XP_016869605.1; XM_017014116.1.
DR RefSeq; XP_016869606.1; XM_017014117.1.
DR AlphaFoldDB; O94819; -.
DR SMR; O94819; -.
DR BioGRID; 115248; 3.
DR STRING; 9606.ENSP00000321544; -.
DR iPTMnet; O94819; -.
DR PhosphoSitePlus; O94819; -.
DR SwissPalm; O94819; -.
DR BioMuta; KBTBD11; -.
DR EPD; O94819; -.
DR jPOST; O94819; -.
DR MassIVE; O94819; -.
DR MaxQB; O94819; -.
DR PaxDb; O94819; -.
DR PeptideAtlas; O94819; -.
DR PRIDE; O94819; -.
DR ProteomicsDB; 50462; -.
DR Antibodypedia; 63434; 34 antibodies from 13 providers.
DR DNASU; 9920; -.
DR Ensembl; ENST00000320248.4; ENSP00000321544.3; ENSG00000176595.4.
DR Ensembl; ENST00000617214.2; ENSP00000481889.1; ENSG00000273645.2.
DR GeneID; 9920; -.
DR KEGG; hsa:9920; -.
DR MANE-Select; ENST00000320248.4; ENSP00000321544.3; NM_014867.3; NP_055682.1.
DR UCSC; uc003wpw.5; human.
DR CTD; 9920; -.
DR DisGeNET; 9920; -.
DR GeneCards; KBTBD11; -.
DR HGNC; HGNC:29104; KBTBD11.
DR HPA; ENSG00000176595; Low tissue specificity.
DR MIM; 618794; gene.
DR neXtProt; NX_O94819; -.
DR OpenTargets; ENSG00000176595; -.
DR PharmGKB; PA142671642; -.
DR VEuPathDB; HostDB:ENSG00000176595; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000161983; -.
DR HOGENOM; CLU_020313_2_0_1; -.
DR InParanoid; O94819; -.
DR OMA; CAMCVLY; -.
DR OrthoDB; 594274at2759; -.
DR PhylomeDB; O94819; -.
DR TreeFam; TF328485; -.
DR PathwayCommons; O94819; -.
DR SignaLink; O94819; -.
DR BioGRID-ORCS; 9920; 19 hits in 1106 CRISPR screens.
DR ChiTaRS; KBTBD11; human.
DR GenomeRNAi; 9920; -.
DR Pharos; O94819; Tdark.
DR PRO; PR:O94819; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; O94819; protein.
DR Bgee; ENSG00000176595; Expressed in cortical plate and 99 other tissues.
DR Genevisible; O94819; HS.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..623
FT /note="Kelch repeat and BTB domain-containing protein 11"
FT /id="PRO_0000119090"
FT DOMAIN 140..196
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 311..359
FT /note="Kelch 1"
FT REPEAT 360..412
FT /note="Kelch 2"
FT REPEAT 413..455
FT /note="Kelch 3"
FT REPEAT 458..500
FT /note="Kelch 4"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BNW9"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BNW9"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
SQ SEQUENCE 623 AA; 65720 MW; 1044C753A8F478C6 CRC64;
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP PQSLASAAEG
AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP EEPAAPSPEP RVWLEDPASP
EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR LRAHKAVLAA RSDYFRARAS RDVLRVQGVS
LTALRLLLAD AYSGRMAGVR PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL
SAAKRQRLNE LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR GCGLCVLYNY
LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ ARSQLRLLAL DGHLYAVGGE
CLLSVERYDP RADRWAPVAP LPRGAFAVAH EATTCHGEIY VSGGSLFYRL LKYDPRRDEW
QECPCSSSRE RSADMVALDG FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP
LRLPGGPTGL QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
RGVLIPFALS LPEKPPRGEQ GAP
