KBTBB_MOUSE
ID KBTBB_MOUSE Reviewed; 633 AA.
AC Q8BNW9; A3KME3;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Kelch repeat and BTB domain-containing protein 11;
GN Name=Kbtbd11; Synonyms=Kiaa0711;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Aorta, and Vein;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain cortex;
RX PubMed=17114649; DOI=10.1074/mcp.m600046-mcp200;
RA Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
RA Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B.,
RA Panse C., Schlapbach R., Mansuy I.M.;
RT "Qualitative and quantitative analyses of protein phosphorylation in naive
RT and stimulated mouse synaptosomal preparations.";
RL Mol. Cell. Proteomics 6:283-293(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-73; SER-92; SER-95
RP AND SER-107, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98007.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129197; BAC98007.1; ALT_INIT; mRNA.
DR EMBL; AK080001; BAC37803.1; -; mRNA.
DR EMBL; BC080858; AAH80858.1; -; mRNA.
DR CCDS; CCDS52493.1; -.
DR RefSeq; NP_083392.1; NM_029116.2.
DR RefSeq; XP_006508978.1; XM_006508915.1.
DR RefSeq; XP_006508979.1; XM_006508916.2.
DR AlphaFoldDB; Q8BNW9; -.
DR SMR; Q8BNW9; -.
DR BioGRID; 217065; 2.
DR IntAct; Q8BNW9; 3.
DR MINT; Q8BNW9; -.
DR STRING; 10090.ENSMUSP00000068321; -.
DR iPTMnet; Q8BNW9; -.
DR PhosphoSitePlus; Q8BNW9; -.
DR SwissPalm; Q8BNW9; -.
DR EPD; Q8BNW9; -.
DR jPOST; Q8BNW9; -.
DR MaxQB; Q8BNW9; -.
DR PaxDb; Q8BNW9; -.
DR PeptideAtlas; Q8BNW9; -.
DR PRIDE; Q8BNW9; -.
DR ProteomicsDB; 269447; -.
DR Antibodypedia; 63434; 34 antibodies from 13 providers.
DR Ensembl; ENSMUST00000069399; ENSMUSP00000068321; ENSMUSG00000055675.
DR Ensembl; ENSMUST00000183471; ENSMUSP00000139292; ENSMUSG00000055675.
DR GeneID; 74901; -.
DR KEGG; mmu:74901; -.
DR UCSC; uc009kzk.2; mouse.
DR CTD; 9920; -.
DR MGI; MGI:1922151; Kbtbd11.
DR VEuPathDB; HostDB:ENSMUSG00000055675; -.
DR eggNOG; KOG1072; Eukaryota.
DR GeneTree; ENSGT00940000161983; -.
DR HOGENOM; CLU_020313_2_0_1; -.
DR InParanoid; Q8BNW9; -.
DR OMA; CAMCVLY; -.
DR OrthoDB; 594274at2759; -.
DR PhylomeDB; Q8BNW9; -.
DR TreeFam; TF328485; -.
DR BioGRID-ORCS; 74901; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Kbtbd11; mouse.
DR PRO; PR:Q8BNW9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BNW9; protein.
DR Bgee; ENSMUSG00000055675; Expressed in floor plate of midbrain and 236 other tissues.
DR Genevisible; Q8BNW9; MM.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..633
FT /note="Kelch repeat and BTB domain-containing protein 11"
FT /id="PRO_0000119091"
FT DOMAIN 146..206
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 317..365
FT /note="Kelch 1"
FT REPEAT 366..418
FT /note="Kelch 2"
FT REPEAT 419..463
FT /note="Kelch 3"
FT REPEAT 465..506
FT /note="Kelch 4"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 70
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O94819"
FT CONFLICT 173
FT /note="A -> S (in Ref. 2; BAC37803)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="L -> V (in Ref. 1; BAC98007)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 633 AA; 67946 MW; 2D37E3C68C98EC73 CRC64;
MENSVAPFVL YSGTEPRTPG EDSLPLPAEE EGAASTAQTP CSLSASLCFS SGDDSPPQSR
ASAAEGSEAS PPSLRSDLRV VETQWDVSSA ASPESPEECA RPEEPASPED PPSRHEHARP
VELESLDELG EPVPVPPGVG SVHGEPDLVI EVAGRRLRAH KAVLAARSDY FRARASRDVL
RVQGVSFTAL RLLLADAYSG RMAGVRPDNV AEVVAGARRL QLPGAAQRAT EAMAPQLSLD
NCYEVLSAGK RQRLTELRDA AYRFMSDHYL EVLREPAVFG RLSGAERDLL LRRRLCTGRA
CLLAAALGTT GERSGSRPQS PSGDAESRGD AAVYCYQAEA GEWRELTRLP EGAPARGCGL
CVLFNYLFLA GGVAPAGPDG RARPSDQVYC YNPVTDSWST VRPLRQARSQ VQLLALDGHL
YAVGGECLLS VERYDPRADR WTAVAPLPRG AFAVAHEAAT CNGEIYVSGG SLFYRLLKYD
PRRDEWQECP CSSSRERSAD MVALDGFLYR FDLCGSRGEA QAAVGSGGGV SVFRYHCLAK
QWSQCAVHLR PPGAPAGLQP FRCVALDGTI YCVSRAGTWR FVPSQDTEAG SDMGPGGSFE
PEPLGSPLDV RGVLFPFVLN LPEKPDRGEQ GAV
