ID   KBTBC_DANRE             Reviewed;         623 AA.
AC   Q3ZB90;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Kelch repeat and BTB domain-containing protein 12;
DE   AltName: Full=Kelch domain-containing protein 6;
GN   Name=kbtbd12; Synonyms=klhdc6; ORFNames=zgc:113365;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC103489; AAI03490.1; -; mRNA.
DR   RefSeq; NP_001029089.1; NM_001033917.2.
DR   AlphaFoldDB; Q3ZB90; -.
DR   SMR; Q3ZB90; -.
DR   STRING; 7955.ENSDARP00000038002; -.
DR   PaxDb; Q3ZB90; -.
DR   PRIDE; Q3ZB90; -.
DR   Ensembl; ENSDART00000035101; ENSDARP00000038002; ENSDARG00000001882.
DR   Ensembl; ENSDART00000188187; ENSDARP00000145104; ENSDARG00000001882.
DR   GeneID; 559380; -.
DR   KEGG; dre:559380; -.
DR   CTD; 166348; -.
DR   ZFIN; ZDB-GENE-050904-1; kbtbd12.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000156836; -.
DR   HOGENOM; CLU_004253_14_6_1; -.
DR   InParanoid; Q3ZB90; -.
DR   OMA; GIGCLGR; -.
DR   OrthoDB; 267586at2759; -.
DR   PhylomeDB; Q3ZB90; -.
DR   TreeFam; TF351656; -.
DR   PRO; PR:Q3ZB90; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000001882; Expressed in muscle tissue and 12 other tissues.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011498; Kelch_2.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF07646; Kelch_2; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..623
FT                   /note="Kelch repeat and BTB domain-containing protein 12"
FT                   /id="PRO_0000324768"
FT   DOMAIN          25..92
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          127..236
FT                   /note="BACK"
FT   REPEAT          390..440
FT                   /note="Kelch 1"
FT   REPEAT          441..496
FT                   /note="Kelch 2"
FT   REPEAT          498..551
FT                   /note="Kelch 3"
FT   REPEAT          557..607
FT                   /note="Kelch 4"
SQ   SEQUENCE   623 AA;  70255 MW;  D150E58792C92857 CRC64;
     MDLRAKHGLT LLEQLNRMRD AEQLTDVVLV AEGVSFPCHR AVLSAFSPYF RVMFTCGLRE
     CSNRQVVLRD MPAPSLALLL EYMYSSNLPL TADNVQGISV AAFLLQMDDV FSRCQIYMID
     NMDTTNCLGI YYYARDLGAE ELADQAQRYL RQHFTEVCYG EEVLELEAHQ LGALLSSDDL
     NVSREESILD VVMRWVKYCP GDVGSEEENR ARHLPELLKK VRLPLVGVDY LKGTMKRNTA
     LLVDAECLQI MEEAIEAASL DSDAPPRRLK LRYGMETTDL LLCIGNEGGG IRSRYGSYTE
     RSFCYAPTTG RTLFITSPRY GEALGYVFAG VVTEKNEIVV SGELGARKMA RHKDKNVEIF
     MYNKEAQGSW KHLSSAEYRD SYALSSLGEN LYLIGGQMKL KNQYHITNSV ERWSLQGGPW
     RSTAPLPMPL AYHSVVRMKG RLYVLGGRTP QSFRTDDEPD RMSNRLLEYD PETNKWNELG
     PMKFSKYRCS AVALNGEIYV LGGIGCEGVD RGQSRYCLNV VEIYNPDGDF WRDGPPLPWP
     LLTLRSNASN AGVVDGKLYV CGYYKGADRH DTITKDILQL DPWENVWTVV AKQALMHDSY
     DVCLVANLNP RGLMPPPADL VEE