ID   KBX12_MESEU             Reviewed;          91 AA.
AC   A9XE59;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Potassium channel toxin MeuTXK-beta-2;
DE            Short=MeuTXKbeta2;
DE   Flags: Precursor;
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20045493; DOI=10.1016/j.bbapap.2009.12.017;
RA   Zhu S., Gao B., Aumelas A., Del Carmen Rodriguez M., Lanz-Mendoza H.,
RA   Peigneur S., Diego-Garcia E., Martin-Eauclaire M.-F., Tytgat J.,
RA   Possani L.D.;
RT   "MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-
RT   like peptide with cytolytic activity.";
RL   Biochim. Biophys. Acta 1804:872-883(2010).
CC   -!- FUNCTION: Has a low affinity binding to potassium channels of rat brain
CC       synaptosomes. Displays weak antibacterial activity against
CC       Stenotrophomonas sp. Strongly inhibits the development of the
CC       Plasmodium berghei ookinetes. Displays slight hemolytic effect on mouse
CC       erythrocytes. Induces cytolysis on Xenopus oocytes at high
CC       concentrations. Is not toxic on mice and on the insect Tenebrio molitor
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EF190324; ABP35518.1; -; mRNA.
DR   AlphaFoldDB; A9XE59; -.
DR   BMRB; A9XE59; -.
DR   SMR; A9XE59; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cytolysis; Disulfide bond; Hemolysis;
KW   Ion channel impairing toxin; Potassium channel impairing toxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..91
FT                   /note="Potassium channel toxin MeuTXK-beta-2"
FT                   /id="PRO_0000394023"
FT   DOMAIN          54..91
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        64..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        68..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ   SEQUENCE   91 AA;  10328 MW;  C2856B4A0440C682 CRC64;
     MQRNLVVLLF LGMVALSSCG FREKHFQRFV KYAVPESTLR TVLQTVVHKV GKTQFGCSAY
     QGYCDDHCQD IEKKEGFCHG FKCKCGIPMG F