位置:首页 > 蛋白库 > KBX1_MESGB
KBX1_MESGB
ID   KBX1_MESGB              Reviewed;          91 AA.
AC   A0A059UI30;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   03-SEP-2014, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Potassium channel toxin Meg-beta-KTx1 {ECO:0000303|PubMed:24746279};
DE            Short=MegbetaKTx1 {ECO:0000303|PubMed:24746279};
DE   AltName: Full=Beta potassium channel toxin 1 {ECO:0000303|PubMed:24746279};
DE   Flags: Precursor;
OS   Mesobuthus gibbosus (Mediterranean checkered scorpion) (Buthus gibbosus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=123226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24746279; DOI=10.1186/1471-2164-15-295;
RA   Diego-Garcia E., Caliskan F., Tytgat J.;
RT   "The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae):
RT   transcriptome analysis and organization of the genome encoding chlorotoxin-
RT   like peptides.";
RL   BMC Genomics 15:295-295(2014).
CC   -!- FUNCTION: Blocks voltage-gated potassium channels.
CC       {ECO:0000250|UniProtKB:P0C2F3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C2F3}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 1
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KF770824; AHZ63133.1; -; mRNA.
DR   AlphaFoldDB; A0A059UI30; -.
DR   SMR; A0A059UI30; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..27
FT                   /evidence="ECO:0000250|UniProtKB:Q9N661"
FT                   /id="PRO_0000433151"
FT   CHAIN           28..91
FT                   /note="Potassium channel toxin Meg-beta-KTx1"
FT                   /id="PRO_0000433152"
FT   DOMAIN          54..91
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        64..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        68..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ   SEQUENCE   91 AA;  10211 MW;  D3328A2927237B83 CRC64;
     MQRNLVVLLF LGMVALSSCG LREKHFQKLV KYAVPEGTLR TIIQTAVHKL GKTQFGCPAY
     QGYCDDHCQD IKKQEGFCHG FKCKCGIPMG F
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024