KBX1_MESGB
ID KBX1_MESGB Reviewed; 91 AA.
AC A0A059UI30;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Potassium channel toxin Meg-beta-KTx1 {ECO:0000303|PubMed:24746279};
DE Short=MegbetaKTx1 {ECO:0000303|PubMed:24746279};
DE AltName: Full=Beta potassium channel toxin 1 {ECO:0000303|PubMed:24746279};
DE Flags: Precursor;
OS Mesobuthus gibbosus (Mediterranean checkered scorpion) (Buthus gibbosus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX NCBI_TaxID=123226;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24746279; DOI=10.1186/1471-2164-15-295;
RA Diego-Garcia E., Caliskan F., Tytgat J.;
RT "The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae):
RT transcriptome analysis and organization of the genome encoding chlorotoxin-
RT like peptides.";
RL BMC Genomics 15:295-295(2014).
CC -!- FUNCTION: Blocks voltage-gated potassium channels.
CC {ECO:0000250|UniProtKB:P0C2F3}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C2F3}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 1
CC subfamily. {ECO:0000305}.
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DR EMBL; KF770824; AHZ63133.1; -; mRNA.
DR AlphaFoldDB; A0A059UI30; -.
DR SMR; A0A059UI30; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR Pfam; PF14866; Toxin_38; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..27
FT /evidence="ECO:0000250|UniProtKB:Q9N661"
FT /id="PRO_0000433151"
FT CHAIN 28..91
FT /note="Potassium channel toxin Meg-beta-KTx1"
FT /id="PRO_0000433152"
FT DOMAIN 54..91
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 57..78
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 64..83
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 68..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ SEQUENCE 91 AA; 10211 MW; D3328A2927237B83 CRC64;
MQRNLVVLLF LGMVALSSCG LREKHFQKLV KYAVPEGTLR TIIQTAVHKL GKTQFGCPAY
QGYCDDHCQD IKKQEGFCHG FKCKCGIPMG F