ID   KBX1_MESMA              Reviewed;          91 AA.
AC   Q9N661;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Potassium channel toxin BmTXK-beta-2;
DE            Short=BmTX K beta2';
DE            Short=BmTXKbeta2;
DE            Short=Toxin BmTX K-beta2;
DE   AltName: Full=Potassium channel toxin beta-KTx 4;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=10471839; DOI=10.1016/s0014-5793(99)01101-1;
RA   Zhu S.-Y., Li W.-X., Zeng X.-C., Jiang D.-H., Mao X., Liu H.;
RT   "Molecular cloning and sequencing of two 'short chain' and two 'long chain'
RT   K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii
RT   Karsch.";
RL   FEBS Lett. 457:509-514(1999).
CC   -!- FUNCTION: Blocks voltage-gated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF155370; AAF31479.1; -; mRNA.
DR   EMBL; AF156173; AAF29466.1; -; mRNA.
DR   AlphaFoldDB; Q9N661; -.
DR   SMR; Q9N661; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..27
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000035346"
FT   CHAIN           28..91
FT                   /note="Potassium channel toxin BmTXK-beta-2"
FT                   /id="PRO_0000035347"
FT   DOMAIN          54..91
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        64..83
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        68..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ   SEQUENCE   91 AA;  10212 MW;  D32850E927237B83 CRC64;
     MQRNLVVLLF LGMVALSSCG LREKHFQKLV KYAVPEGTLR TIIQTAVHKL GKTQFGCPAY
     QGYCDDHCQD IKKEEGFCHG FKCKCGIPMG F