ID   KBX1_TITTR              Reviewed;          87 AA.
AC   Q0GY46; A8SDT0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Potassium channel toxin Ttr-beta-KTx;
DE            Short=TtrbetaKTx;
DE   Flags: Precursor;
OS   Tityus trivittatus (Argentinean scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=369776;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=17141373; DOI=10.1016/j.peptides.2006.06.012;
RA   Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V.,
RA   Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.;
RT   "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like
RT   peptides in scorpion venoms: identification of 'orphan' components.";
RL   Peptides 28:31-37(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
RA   Diego-Garcia E., Schwartz E.F., Rodriguez de la Vega R.C., Possani L.D.;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE REVISION TO 64; 76 AND 78.
RX   PubMed=20045493; DOI=10.1016/j.bbapap.2009.12.017;
RA   Zhu S., Gao B., Aumelas A., Del Carmen Rodriguez M., Lanz-Mendoza H.,
RA   Peigneur S., Diego-Garcia E., Martin-Eauclaire M.-F., Tytgat J.,
RA   Possani L.D.;
RT   "MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-
RT   like peptide with cytolytic activity.";
RL   Biochim. Biophys. Acta 1804:872-883(2010).
CC   -!- FUNCTION: Blocks voltage-gated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; DQ465345; ABE98261.1; -; mRNA.
DR   EMBL; EF613115; ABU94955.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0GY46; -.
DR   SMR; Q0GY46; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..27
FT                   /id="PRO_0000274678"
FT   CHAIN           28..87
FT                   /note="Potassium channel toxin Ttr-beta-KTx"
FT                   /id="PRO_0000274679"
FT   DOMAIN          53..87
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        56..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        63..82
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        67..84
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   CONFLICT        37..38
FT                   /note="TV -> QL (in Ref. 2; ABU94955)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   87 AA;  9807 MW;  7C226546E3E44C02 CRC64;
     MERKWALLLF LGMVTLVSCG LREKHVQKLV ALIPNDTVRS ILKAVVHKAA KTQFGCPAYE
     GYCNNHCQDI KRKDGECHGF KCKCAKD