KBX21_LYCMC
ID KBX21_LYCMC Reviewed; 89 AA.
AC P0CJ45;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Neurotoxin beta-KTx 52.1;
DE Flags: Precursor;
OS Lychas mucronatus (Chinese swimming scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX NCBI_TaxID=172552;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Yunnan; TISSUE=Venom gland;
RX PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT mucronatus reveals intraspecific toxic gene diversity and new venomous
RT components.";
RL BMC Genomics 11:452-452(2010).
CC -!- FUNCTION: Inhibits voltage-gated potassium channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 2
CC subfamily. {ECO:0000305}.
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DR EMBL; GT028908; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0CJ45; -.
DR SMR; P0CJ45; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR Pfam; PF14866; Toxin_38; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..39
FT /evidence="ECO:0000305"
FT /id="PRO_0000403846"
FT CHAIN 40..89
FT /note="Neurotoxin beta-KTx 52.1"
FT /id="PRO_0000403847"
FT DOMAIN 53..89
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 56..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 63..81
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 67..83
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ SEQUENCE 89 AA; 9925 MW; A54538231A2A2FA3 CRC64;
MKQYIFFLAL IVLTATFAEA GKKTEILDKV KKVFSKAKDK VLAGVEDLNN MSELGCPFID
KWCEDHCDSK KLVGKCENFD CSCVKLGGK