ID   KBX23_LYCMC             Reviewed;          85 AA.
AC   P0CI42;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=Neurotoxin beta-KTx 14.3;
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND ALTERNATIVE
RP   SPLICING.
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Isoform 1 has a very weak effect to block voltage-gated
CC       potassium channel Kv1.1/KCNA1. {ECO:0000269|PubMed:20663230}.
CC   -!- FUNCTION: Isoform 2 has a very weak effect to block voltage-gated
CC       potassium channel Kv1.1/KCNA1. {ECO:0000269|PubMed:20663230}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P0CI42-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P0CI42-2; Sequence=VSP_040456;
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; GT028643; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; GT028645; -; NOT_ANNOTATED_CDS; mRNA.
DR   PDB; 7LGV; NMR; -; A=38-85.
DR   PDBsum; 7LGV; -.
DR   AlphaFoldDB; P0CI42; -.
DR   SMR; P0CI42; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin; Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..37
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000403850"
FT   CHAIN           38..85
FT                   /note="Neurotoxin beta-KTx 14.3"
FT                   /id="PRO_0000403851"
FT   DOMAIN          49..85
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        52..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        59..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        63..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   VAR_SEQ         37..39
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:20663230"
FT                   /id="VSP_040456"
SQ   SEQUENCE   85 AA;  9425 MW;  4647B291E448A789 CRC64;
     MKQYIFFLAL IVLTATFAEA GKKTEILDKV KKVFSKGIAG VADLNNMSEL GCPFIEKWCE
     DHCESKKQVG KCENFDCSCV KLGGK