ID   KBX27_LYCMC             Reviewed;          85 AA.
AC   C6ZH27; C6ZH28;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Neurotoxin beta-KTx 17;
DE   AltName: Full=Neurotoxin KTx6;
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Hainan;
RA   Ma Y., Cao Z.-J., Li W.-X.;
RT   "Alternative splicing contributes to diversity of scorpion venom
RT   peptides.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   ALTERNATIVE SPLICING.
RC   STRAIN=Yunnan;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Isoform 1 has a very weak effect to block voltage-gated
CC       potassium channel Kv1.1/KCNA1.
CC   -!- FUNCTION: Isoform 2 has a very weak effect to block voltage-gated
CC       potassium channel Kv1.1/KCNA1.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=C6ZH27-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=C6ZH27-2; Sequence=VSP_040457;
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 2
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU877535; ACJ63719.1; -; Genomic_DNA.
DR   EMBL; EU877536; ACJ63720.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6ZH27; -.
DR   SMR; C6ZH27; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..37
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403852"
FT   CHAIN           38..85
FT                   /note="Neurotoxin beta-KTx 17"
FT                   /id="PRO_0000403853"
FT   DOMAIN          49..85
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        52..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        59..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        63..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   VAR_SEQ         37..39
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_040457"
SQ   SEQUENCE   85 AA;  9439 MW;  44DB7CC36E48BFF2 CRC64;
     MKQYIFFLAL IVLVSTFAEA GKKTEILDKV KKVFSKGIAG VADLNNMSEL GCPFIEKWCE
     DHCESKKQVG KCENFDCSCV KLGGK