KBX2_HOFGE
ID KBX2_HOFGE Reviewed; 79 AA.
AC Q0GY41;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Potassium channel toxin Hge-beta-KTx;
DE Short=HgebetaKTx;
DE Flags: Precursor;
OS Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Iuroidea; Hadrurus.
OX NCBI_TaxID=380989;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=17506894; DOI=10.1186/1471-2164-8-119;
RA Schwartz E.F., Diego-Garcia E., Rodriguez de la Vega R.C., Possani L.D.;
RT "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus
RT gertschi (Arachnida: Scorpiones).";
RL BMC Genomics 8:119-119(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-59, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom, and Venom gland;
RX PubMed=17141373; DOI=10.1016/j.peptides.2006.06.012;
RA Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V.,
RA Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.;
RT "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like
RT peptides in scorpion venoms: identification of 'orphan' components.";
RL Peptides 28:31-37(2007).
RN [3]
RP PROTEIN SEQUENCE OF 22-59, AND FUNCTION.
RX PubMed=18030427; DOI=10.1007/s00018-007-7370-x;
RA Diego-Garcia E., Abdel-Mottaleb Y., Schwartz E.F.,
RA Rodriguez de la Vega R.C., Tytgat J., Possani L.D.;
RT "Cytolytic and K+ channel blocking activities of beta-KTx and scorpine-like
RT peptides purified from scorpion venoms.";
RL Cell. Mol. Life Sci. 65:187-200(2008).
CC -!- FUNCTION: The full peptide presents antibacterial and cytotoxic
CC activities. The C-terminus (33-76aa) blocks potassium channels
CC Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.3/KCNA3.
CC {ECO:0000269|PubMed:18030427}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MASS SPECTROMETRY: Mass=6427.0; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17141373};
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 2
CC subfamily. {ECO:0000305}.
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DR EMBL; DQ465350; ABE98266.1; -; mRNA.
DR EMBL; EL698909; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q0GY41; -.
DR SMR; Q0GY41; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR Pfam; PF14866; Toxin_38; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Neurotoxin; Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..79
FT /note="Potassium channel toxin Hge-beta-KTx"
FT /id="PRO_0000274688"
FT DOMAIN 48..79
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 51..71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 58..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 62..78
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ SEQUENCE 79 AA; 8689 MW; B8E6F447F845CEE8 CRC64;
MAKSFFAAFL IIMLISSLVD GKSTVGQKLK KKLNQAVDKV KEVLNKSEYM CPVVSSFCKQ
HCARLGKSGQ CDLLECICS