KBX2_TITTR
ID KBX2_TITTR Reviewed; 91 AA.
AC Q0GY45; A8U076;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Potassium channel toxin TtrKIK;
DE Flags: Precursor;
OS Tityus trivittatus (Argentinean scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX NCBI_TaxID=369776;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=17141373; DOI=10.1016/j.peptides.2006.06.012;
RA Diego-Garcia E., Schwartz E.F., D'Suze G., Gonzalez S.A., Batista C.V.,
RA Garcia B.I., Rodriguez de la Vega R.C., Possani L.D.;
RT "Wide phylogenetic distribution of scorpine and long-chain beta-KTx-like
RT peptides in scorpion venoms: identification of 'orphan' components.";
RL Peptides 28:31-37(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Diego-Garcia E., Schwartz E.F., Rodriguez de la Vega R.C., Possani L.D.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Blocks voltage-gated potassium channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 2
CC subfamily. {ECO:0000305}.
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DR EMBL; DQ465346; ABE98262.1; -; mRNA.
DR EMBL; EU089740; ABV64385.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0GY45; -.
DR SMR; Q0GY45; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR Pfam; PF14866; Toxin_38; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..44
FT /evidence="ECO:0000250"
FT /id="PRO_0000274686"
FT CHAIN 45..91
FT /note="Potassium channel toxin TtrKIK"
FT /id="PRO_0000274687"
FT DOMAIN 58..91
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 61..81
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 68..86
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 72..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ SEQUENCE 91 AA; 10067 MW; 0FBFD2226490CD99 CRC64;
MVATNRCCVF ALLFALLLVH SLTEAGKGKE VLGKIKDKLI EAKDKIKSGW ERLTSQSEYA
CPAIEKFCED HCAAKKAVGK CDDFKCNCIK L