KBX31_UROYA
ID KBX31_UROYA Reviewed; 94 AA.
AC L0G8Z0;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2013, sequence version 1.
DT 25-MAY-2022, entry version 19.
DE RecName: Full=Antimicrobial peptide scorpine-like-1;
DE Short=SCl1;
DE Flags: Precursor;
OS Urodacus yaschenkoi (Inland robust scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Urodacinae; Urodacus.
OX NCBI_TaxID=1273102;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=23182832; DOI=10.1016/j.toxicon.2012.11.017;
RA Luna-Ramirez K., Quintero-Hernandez V., Vargas-Jaimes L., Batista C.V.,
RA Winkel K.D., Possani L.D.;
RT "Characterization of the venom from the Australian scorpion Urodacus
RT yaschenkoi: molecular mass analysis of components, cDNA sequences and
RT peptides with antimicrobial activity.";
RL Toxicon 63:44-54(2013).
CC -!- FUNCTION: Has antimicrobial activity against yeasts and bacteria.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 3
CC subfamily. {ECO:0000305}.
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DR EMBL; JX274244; AGA82758.1; -; mRNA.
DR AlphaFoldDB; L0G8Z0; -.
DR SMR; L0G8Z0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR Pfam; PF14866; Toxin_38; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Disulfide bond; Fungicide; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..94
FT /note="Antimicrobial peptide scorpine-like-1"
FT /id="PRO_5001091930"
FT DOMAIN 54..94
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 57..81
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 67..86
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 71..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ SEQUENCE 94 AA; 10642 MW; E042E363C3010333 CRC64;
MNTKFTVLIF LGVIVVSYGW ITEKKIQKVL DEKLPNGFIK GAAKAVVHKL AKSEYGCMMD
ISWNKDCQRH CQSTEQKDGI CHGMKCKCGK PRSY