ID   KBX32_HOFGE             Reviewed;         101 AA.
AC   P0C8W5;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Hg-scorpine-like 2;
DE            Short=HgeScplp2;
DE            Short=Hgscplike2;
DE   Flags: Precursor;
OS   Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Iuroidea; Hadrurus.
OX   NCBI_TaxID=380989;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=17506894; DOI=10.1186/1471-2164-8-119;
RA   Schwartz E.F., Diego-Garcia E., Rodriguez de la Vega R.C., Possani L.D.;
RT   "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus
RT   gertschi (Arachnida: Scorpiones).";
RL   BMC Genomics 8:119-119(2007).
CC   -!- FUNCTION: Has antimicrobial activity against yeasts and bacteria.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EL698900; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0C8W5; -.
DR   SMR; P0C8W5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Disulfide bond; Fungicide; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..101
FT                   /note="Hg-scorpine-like 2"
FT                   /id="PRO_0000366103"
FT   DOMAIN          60..100
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        63..87
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        73..92
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        77..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ   SEQUENCE   101 AA;  11206 MW;  EB2EFADFC4B7080F CRC64;
     MKLTILILLV ITSFCSCGIL REKYAHKAID VLTPMIGVPV VSKIVNNAAK QLVHKIAKNQ
     QLCMFNKDVA GWCEKSCQQS AHQKGYCHGT KCKCGIPLNY K