KBX32_OPICA
ID KBX32_OPICA Reviewed; 95 AA.
AC Q5WR01; Q5WR02;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Opiscorpine-2;
DE Flags: Precursor;
OS Opistophthalmus carinatus (African yellow leg scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Opistophthalminae;
OC Opistophthalmus.
OX NCBI_TaxID=190115;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=15241551; DOI=10.1007/s00018-004-4149-1;
RA Zhu S., Tytgat J.;
RT "The scorpine family of defensins: gene structure, alternative
RT polyadenylation and fold recognition.";
RL Cell. Mol. Life Sci. 61:1751-1763(2004).
CC -!- FUNCTION: Has antimicrobial activity against yeasts and bacteria.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 3
CC subfamily. {ECO:0000305}.
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DR EMBL; AY423483; AAQ94354.1; -; mRNA.
DR EMBL; AY423482; AAQ94353.1; -; mRNA.
DR AlphaFoldDB; Q5WR01; -.
DR SMR; Q5WR01; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR Pfam; PF14866; Toxin_38; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Disulfide bond; Fungicide; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..95
FT /note="Opiscorpine-2"
FT /id="PRO_5000092272"
FT DOMAIN 55..95
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 58..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 68..87
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 72..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT VARIANT 11
FT /note="H -> L"
SQ SEQUENCE 95 AA; 10380 MW; 6FE3B115DFCB7B18 CRC64;
MNNKLTALIF HGLLAIASCK WLNEKSIQNK IDEKIGKNFL GGMAKAVVHK LAKNEFMCMA
NMDPTGSCET HCQKASGEKG YCHGTKCKCG VPLSY