KBX3_HETLA
ID KBX3_HETLA Reviewed; 95 AA.
AC P0C2F4;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=Heteroscorpine-1;
DE Short=HS-1;
DE Flags: Precursor;
OS Heterometrus laoticus (Thai giant scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Heterometrinae;
OC Heterometrus.
OX NCBI_TaxID=217256;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20; 58-71 AND 80-86,
RP MASS SPECTROMETRY, AND TOXIC DOSE.
RC TISSUE=Venom;
RX PubMed=17056081; DOI=10.1016/j.toxicon.2006.09.003;
RA Uawonggul N., Thammasirirak S., Chaveerach A., Arkaravichien T.,
RA Bunyatratchata W., Ruangjirachuporn W., Jearranaiprepame P., Nakamura T.,
RA Matsuda M., Kobayashi M., Hattori S., Daduang S.;
RT "Purification and characterization of Heteroscorpine-1 (HS-1) toxin from
RT Heterometrus laoticus scorpion venom.";
RL Toxicon 49:19-29(2007).
CC -!- FUNCTION: Has antibacterial activity against B.subtilis, K.pneumoniae
CC and P.aeruginosa.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- PTM: Contains 3 disulfide bonds.
CC -!- MASS SPECTROMETRY: Mass=8293; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:17056081};
CC -!- TOXIC DOSE: PD(50) is 80 ul to crickets (Gryllus sp).
CC {ECO:0000269|PubMed:17056081}.
CC -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 3
CC subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C2F4; -.
DR SMR; P0C2F4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR029237; Long_scorpion_toxin.
DR Pfam; PF14866; Toxin_38; 1.
DR PROSITE; PS51862; BSPN_CSAB; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT CHAIN 20..95
FT /note="Heteroscorpine-1"
FT /id="PRO_0000274680"
FT DOMAIN 55..95
FT /note="BetaSPN-type CS-alpha/beta"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 58..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 68..87
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT DISULFID 72..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ SEQUENCE 95 AA; 10246 MW; 21CCE2CD82EFFFA6 CRC64;
MNSKLTALIF LGLVAIASCG WINEEKIQKK IDEKIGNNIL GGMAKAVVHK LAKGEFQCVA
NIDTMGNCET HCQKTSGEKG FCHGTKCKCG KPLSY