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KBX3_PANIM
ID   KBX3_PANIM              Reviewed;          94 AA.
AC   P56972;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Scorpine;
DE            Short=Scorpin;
DE   AltName: Full=Panscorpine;
DE   Flags: Precursor;
OS   Pandinus imperator (Emperor scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Pandininae; Pandinus.
OX   NCBI_TaxID=55084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-94, CHARACTERIZATION,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=10767415; DOI=10.1016/s0014-5793(00)01384-3;
RA   Conde R., Zamudio F.Z., Rodriguez M.H., Possani L.D.;
RT   "Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion
RT   venom.";
RL   FEBS Lett. 471:165-168(2000).
CC   -!- FUNCTION: Has antibacterial activity against B.subtilis and
CC       K.pneumoniae and a potent inhibitory effect on the ookinete (ED(50) 0.7
CC       uM) and gamete (ED(50) 10 uM) stages of Plasmodium berghei development.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=8350; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10767415};
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AJ292361; CAB96789.1; -; mRNA.
DR   PDB; 7M1D; NMR; -; A=48-94.
DR   PDB; 7M1E; NMR; -; A=20-47.
DR   PDBsum; 7M1D; -.
DR   PDBsum; 7M1E; -.
DR   AlphaFoldDB; P56972; -.
DR   SMR; P56972; -.
DR   TCDB; 1.C.47.3.1; the insect/fungal defensin (insect/fungal defensin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:10767415"
FT   CHAIN           20..94
FT                   /note="Scorpine"
FT                   /id="PRO_0000035355"
FT   DOMAIN          55..94
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        58..81
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        68..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        72..88
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   HELIX           22..34
FT                   /evidence="ECO:0007829|PDB:7M1E"
FT   TURN            35..39
FT                   /evidence="ECO:0007829|PDB:7M1E"
FT   HELIX           40..44
FT                   /evidence="ECO:0007829|PDB:7M1E"
FT   TURN            57..59
FT                   /evidence="ECO:0007829|PDB:7M1D"
FT   TURN            61..63
FT                   /evidence="ECO:0007829|PDB:7M1D"
FT   TURN            69..72
FT                   /evidence="ECO:0007829|PDB:7M1D"
FT   HELIX           73..75
FT                   /evidence="ECO:0007829|PDB:7M1D"
FT   STRAND          77..80
FT                   /evidence="ECO:0007829|PDB:7M1D"
FT   STRAND          87..89
FT                   /evidence="ECO:0007829|PDB:7M1D"
SQ   SEQUENCE   94 AA;  10394 MW;  04E57F04BAECC89F CRC64;
     MNSKLTALIF LGLIAIAYCG WINEEKIQKK IDERMGNTVL GGMAKAIVHK MAKNEFQCMA
     NMDMLGNCEK HCQTSGEKGY CHGTKCKCGT PLSY
 
 
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