KC1DB_DANRE
ID KC1DB_DANRE Reviewed; 409 AA.
AC Q6P3K7; Q4V962;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Casein kinase I isoform delta-B;
DE Short=CKI-delta-B;
DE Short=CKId-B;
DE EC=2.7.11.1;
GN Name=csnk1db;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=18064361; DOI=10.4067/s0716-97602007000200015;
RA Albornoz A., Yanez J.M., Foerster C., Aguirre C., Pereiro L., Burzio V.,
RA Moraga M., Reyes A.E., Antonelli M.;
RT "The CK1 gene family: expression patterning in zebrafish development.";
RL Biol. Res. 40:251-266(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Casein kinases are operationally defined by their
CC preferential utilization of acidic proteins such as caseins as
CC substrates. Central component of the circadian clock. May act as a
CC negative regulator of circadian rhythmicity by phosphorylating per1 and
CC per2, which may lead to their degradation. Participates in wnt
CC signaling (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- ACTIVITY REGULATION: Exhibits substrate-dependent heparin activation.
CC {ECO:0000250}.
CC -!- SUBUNIT: Monomer (By similarity). Interacts with per1 and per2.
CC Component of the circadian core oscillator (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Ubiquitously expressed in embryos until eight
CC hours after fertilization. Highly expressed in the developing neural
CC plate eight hours after fertilization. Detected in telencephalon,
CC retina, diencephalon, mesencephalon, cerebellum and rhombomeres between
CC 24 and 38 hours after fertilization. Detected in tegmentum,
CC myencephalon and notochord 48 hours after fertilization.
CC {ECO:0000269|PubMed:18064361}.
CC -!- PTM: Autophosphorylated on serine and threonine residues.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000305}.
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DR EMBL; EU127825; ABV29337.1; -; mRNA.
DR EMBL; BC063953; AAH63953.1; -; mRNA.
DR EMBL; BC097045; AAH97045.1; -; mRNA.
DR RefSeq; NP_998415.1; NM_213250.1.
DR AlphaFoldDB; Q6P3K7; -.
DR SMR; Q6P3K7; -.
DR STRING; 7955.ENSDARP00000014900; -.
DR PaxDb; Q6P3K7; -.
DR Ensembl; ENSDART00000021491; ENSDARP00000014900; ENSDARG00000006125.
DR Ensembl; ENSDART00000188988; ENSDARP00000153828; ENSDARG00000006125.
DR GeneID; 406533; -.
DR KEGG; dre:406533; -.
DR CTD; 406533; -.
DR ZFIN; ZDB-GENE-040426-2385; csnk1db.
DR eggNOG; KOG1164; Eukaryota.
DR GeneTree; ENSGT00940000153536; -.
DR HOGENOM; CLU_019279_2_2_1; -.
DR InParanoid; Q6P3K7; -.
DR OMA; PHGLANV; -.
DR OrthoDB; 1097975at2759; -.
DR PhylomeDB; Q6P3K7; -.
DR TreeFam; TF300544; -.
DR Reactome; R-DRE-204005; COPII-mediated vesicle transport.
DR Reactome; R-DRE-2565942; Regulation of PLK1 Activity at G2/M Transition.
DR Reactome; R-DRE-380259; Loss of Nlp from mitotic centrosomes.
DR Reactome; R-DRE-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-DRE-380284; Loss of proteins required for interphase microtubule organization from the centrosome.
DR Reactome; R-DRE-380320; Recruitment of NuMA to mitotic centrosomes.
DR Reactome; R-DRE-5620912; Anchoring of the basal body to the plasma membrane.
DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DRE-8854518; AURKA Activation by TPX2.
DR PRO; PR:Q6P3K7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 12.
DR Bgee; ENSDARG00000006125; Expressed in early embryo and 42 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0042752; P:regulation of circadian rhythm; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW Reference proteome; Serine/threonine-protein kinase; Transferase;
KW Wnt signaling pathway.
FT CHAIN 1..409
FT /note="Casein kinase I isoform delta-B"
FT /id="PRO_0000354088"
FT DOMAIN 9..277
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 300..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..341
FT /note="Autoinhibitory"
FT /evidence="ECO:0000250"
FT COMPBIAS 300..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 128
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 15..23
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CONFLICT 31
FT /note="V -> I (in Ref. 2; AAH97045)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="C -> R (in Ref. 2; AAH97045)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="N -> D (in Ref. 2; AAH97045)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 409 AA; 46831 MW; 01E418DA8984A787 CRC64;
MELRVGNRYR LGRKIGSGSF GDIYLGTDIS VGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
GGVGIPTIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGANRT
AEEADRERRE RDERMRHSRN PAARGIPAAS GRPRPTQDGA PPTPLTPTSH TANTSSPRPV
TGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQN SIPFDHHGK
