KC5S1_HUMAN
ID KC5S1_HUMAN Reviewed; 145 AA.
AC Q8TAV5; A0A024R3N7; B2RAD0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Uncharacterized protein KCNJ5-AS1 {ECO:0000305};
DE AltName: Full=KCNJ5 antisense RNA 1 {ECO:0000312|HGNC:HGNC:28584};
DE Flags: Precursor;
GN Name=KCNJ5-AS1 {ECO:0000312|HGNC:HGNC:28584};
GN Synonyms=C11orf45 {ECO:0000312|HGNC:HGNC:28584};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TAV5; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-12810853, EBI-743105;
CC Q8TAV5; Q9H4M3-2: FBXO44; NbExp=3; IntAct=EBI-12810853, EBI-12104696;
CC Q8TAV5; O43559: FRS3; NbExp=3; IntAct=EBI-12810853, EBI-725515;
CC Q8TAV5; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-12810853, EBI-347538;
CC Q8TAV5; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-12810853, EBI-742388;
CC Q8TAV5; O43711: TLX3; NbExp=3; IntAct=EBI-12810853, EBI-3939165;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK125634; BAG54227.1; -; mRNA.
DR EMBL; AK314137; BAG36827.1; -; mRNA.
DR EMBL; CH471065; EAW67728.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67729.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67730.1; -; Genomic_DNA.
DR EMBL; BC025756; AAH25756.1; -; mRNA.
DR RefSeq; NP_001243017.1; NM_001256088.1.
DR RefSeq; NP_659450.1; NM_145013.2.
DR RefSeq; XP_011540956.1; XM_011542654.2.
DR RefSeq; XP_011540957.1; XM_011542655.2.
DR AlphaFoldDB; Q8TAV5; -.
DR BioGRID; 128579; 10.
DR IntAct; Q8TAV5; 6.
DR STRING; 9606.ENSP00000307879; -.
DR GlyGen; Q8TAV5; 1 site.
DR iPTMnet; Q8TAV5; -.
DR PhosphoSitePlus; Q8TAV5; -.
DR BioMuta; C11orf45; -.
DR DMDM; 74730393; -.
DR PaxDb; Q8TAV5; -.
DR PRIDE; Q8TAV5; -.
DR Antibodypedia; 51323; 36 antibodies from 10 providers.
DR DNASU; 219833; -.
DR Ensembl; ENST00000310799.9; ENSP00000307879.3; ENSG00000174370.12.
DR Ensembl; ENST00000524878.2; ENSP00000502613.1; ENSG00000174370.12.
DR GeneID; 219833; -.
DR UCSC; uc001qeu.3; human.
DR CTD; 219833; -.
DR DisGeNET; 219833; -.
DR GeneCards; C11orf45; -.
DR HGNC; HGNC:28584; KCNJ5-AS1.
DR HPA; ENSG00000174370; Low tissue specificity.
DR neXtProt; NX_Q8TAV5; -.
DR OpenTargets; ENSG00000174370; -.
DR VEuPathDB; HostDB:ENSG00000174370; -.
DR eggNOG; ENOG502TG9K; Eukaryota.
DR GeneTree; ENSGT00730000112089; -.
DR HOGENOM; CLU_1795847_0_0_1; -.
DR InParanoid; Q8TAV5; -.
DR OMA; AYTHGCG; -.
DR OrthoDB; 956263at2759; -.
DR PhylomeDB; Q8TAV5; -.
DR TreeFam; TF342259; -.
DR PathwayCommons; Q8TAV5; -.
DR SignaLink; Q8TAV5; -.
DR BioGRID-ORCS; 219833; 11 hits in 1054 CRISPR screens.
DR ChiTaRS; C11orf45; human.
DR GenomeRNAi; 219833; -.
DR Pharos; Q8TAV5; Tdark.
DR PRO; PR:Q8TAV5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8TAV5; protein.
DR Bgee; ENSG00000174370; Expressed in right adrenal gland cortex and 110 other tissues.
DR ExpressionAtlas; Q8TAV5; baseline and differential.
DR Genevisible; Q8TAV5; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR041391; DUF5570.
DR Pfam; PF17731; DUF5570; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..145
FT /note="Uncharacterized protein KCNJ5-AS1"
FT /id="PRO_0000251890"
FT REGION 103..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 145 AA; 15559 MW; 89C0997106EBD98F CRC64;
MLTRLVLSAH LSSTTSPPWT HAAISWELDN VLMPSPRIWP QVTPTGRSAS VRSEGNTSSL
WNFSAGQDVH AIVTRTCESV LSSAVYTHGC GCVRSATNIT CQSSGQQRQA ARQEEENSIC
KAHDSREGRL GYPLSAHQPG SGGPN
