KCAB3_HUMAN
ID KCAB3_HUMAN Reviewed; 404 AA.
AC O43448; Q4VAW0;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Voltage-gated potassium channel subunit beta-3;
DE AltName: Full=K(+) channel subunit beta-3;
DE AltName: Full=Kv-beta-3;
GN Name=KCNAB3; Synonyms=KCNA3B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=9857044; DOI=10.1074/jbc.273.52.35095;
RA Leicher T., Baehring R., Isbrandt D., Pongs O.;
RT "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type
RT potassium channel.";
RL J. Biol. Chem. 273:35095-35101(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Accessory potassium channel protein which modulates the
CC activity of the pore-forming alpha subunit. Alters the functional
CC properties of Kv1.5. {ECO:0000269|PubMed:9857044}.
CC -!- SUBUNIT: Forms heteromultimeric complex with alpha subunits.
CC -!- INTERACTION:
CC O43448; O60547: GMDS; NbExp=3; IntAct=EBI-12050557, EBI-746373;
CC O43448; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-12050557, EBI-742388;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain specific. Most prominent expression in
CC cerebellum. Weaker signals detected in cortex, occipital lobe, frontal
CC lobe and temporal lobe. Not detected in spinal cord, heart, lung,
CC liver, kidney, pancreas, placenta and skeletal muscle.
CC {ECO:0000269|PubMed:9857044}.
CC -!- DOMAIN: Alteration of functional properties of alpha subunit is
CC mediated through N-terminal domain of beta subunit. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC family. {ECO:0000305}.
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DR EMBL; AF016411; AAB92499.1; -; mRNA.
DR EMBL; BC096232; AAH96232.1; -; mRNA.
DR EMBL; BC096234; AAH96234.1; -; mRNA.
DR EMBL; BC099634; AAH99634.1; -; mRNA.
DR CCDS; CCDS11124.1; -.
DR RefSeq; NP_004723.2; NM_004732.3.
DR AlphaFoldDB; O43448; -.
DR SMR; O43448; -.
DR BioGRID; 114631; 10.
DR IntAct; O43448; 7.
DR STRING; 9606.ENSP00000302719; -.
DR GlyGen; O43448; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O43448; -.
DR PhosphoSitePlus; O43448; -.
DR BioMuta; KCNAB3; -.
DR jPOST; O43448; -.
DR MassIVE; O43448; -.
DR MaxQB; O43448; -.
DR PaxDb; O43448; -.
DR PeptideAtlas; O43448; -.
DR PRIDE; O43448; -.
DR ProteomicsDB; 48954; -.
DR ABCD; O43448; 1 sequenced antibody.
DR Antibodypedia; 12312; 150 antibodies from 24 providers.
DR DNASU; 9196; -.
DR Ensembl; ENST00000303790.3; ENSP00000302719.2; ENSG00000170049.10.
DR GeneID; 9196; -.
DR KEGG; hsa:9196; -.
DR MANE-Select; ENST00000303790.3; ENSP00000302719.2; NM_004732.4; NP_004723.2.
DR UCSC; uc002gjm.2; human.
DR CTD; 9196; -.
DR DisGeNET; 9196; -.
DR GeneCards; KCNAB3; -.
DR HGNC; HGNC:6230; KCNAB3.
DR HPA; ENSG00000170049; Tissue enhanced (endometrium, retina).
DR MIM; 604111; gene.
DR neXtProt; NX_O43448; -.
DR OpenTargets; ENSG00000170049; -.
DR PharmGKB; PA30024; -.
DR VEuPathDB; HostDB:ENSG00000170049; -.
DR eggNOG; KOG1575; Eukaryota.
DR GeneTree; ENSGT00940000159306; -.
DR HOGENOM; CLU_023205_2_0_1; -.
DR InParanoid; O43448; -.
DR OMA; YSMINRW; -.
DR OrthoDB; 1106773at2759; -.
DR PhylomeDB; O43448; -.
DR TreeFam; TF324563; -.
DR PathwayCommons; O43448; -.
DR Reactome; R-HSA-1296072; Voltage gated Potassium channels.
DR SignaLink; O43448; -.
DR BioGRID-ORCS; 9196; 7 hits in 1070 CRISPR screens.
DR ChiTaRS; KCNAB3; human.
DR GeneWiki; KCNAB3; -.
DR GenomeRNAi; 9196; -.
DR Pharos; O43448; Tbio.
DR PRO; PR:O43448; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O43448; protein.
DR Bgee; ENSG00000170049; Expressed in right hemisphere of cerebellum and 93 other tissues.
DR ExpressionAtlas; O43448; baseline and differential.
DR Genevisible; O43448; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; TAS:ProtInc.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR005983; K_chnl_volt-dep_bsu_KCNAB.
DR InterPro; IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
DR InterPro; IPR005402; K_chnl_volt-dep_bsu_KCNAB3.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43150; PTHR43150; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PRINTS; PR01580; KCNAB3CHANEL.
DR PRINTS; PR01577; KCNABCHANNEL.
DR SUPFAM; SSF51430; SSF51430; 1.
DR TIGRFAMs; TIGR01293; Kv_beta; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Ion channel; Ion transport; Potassium; Potassium transport;
KW Reference proteome; Transport; Voltage-gated channel.
FT CHAIN 1..404
FT /note="Voltage-gated potassium channel subunit beta-3"
FT /id="PRO_0000148750"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 57
FT /note="L -> V (in Ref. 1; AAB92499)"
FT /evidence="ECO:0000305"
FT CONFLICT 60
FT /note="R -> G (in Ref. 1; AAB92499)"
FT /evidence="ECO:0000305"
FT CONFLICT 65
FT /note="A -> G (in Ref. 1; AAB92499)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="L -> V (in Ref. 1; AAB92499)"
FT /evidence="ECO:0000305"
FT CONFLICT 86..88
FT /note="SGL -> CGV (in Ref. 1; AAB92499)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 43670 MW; 57C4FAD8D19D9EBB CRC64;
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG PKARAALVPR
PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT FGSQISDETA EDVLTVAYEH
GVNLFDTAEV YAAGKAERTL GNILKSKGWR RSSYVITTKI FWGGQAETER GLSRKHIIEG
LRGSLERLQL GYVDIVFANR SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY
SMARQFNLIP PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA WCLRSEGVSS
VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP HSKK
