ID   KCAB3_MOUSE             Reviewed;         249 AA.
AC   P97382;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Voltage-gated potassium channel subunit beta-3;
DE   AltName: Full=K(+) channel subunit beta-3;
DE   AltName: Full=Kv-beta-3;
GN   Name=Kcnab3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=8824288; DOI=10.1074/jbc.271.42.26341;
RA   Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J.,
RA   Lazdunski M.;
RT   "A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK)
RT   expression.";
RL   J. Biol. Chem. 271:26341-26348(1996).
CC   -!- FUNCTION: Accessory potassium channel protein which modulates the
CC       activity of the pore-forming alpha subunit. Alters the functional
CC       properties of Kv2.2 but not Kv2.1. {ECO:0000269|PubMed:8824288}.
CC   -!- SUBUNIT: Forms heteromultimeric complex with alpha subunits.
CC   -!- INTERACTION:
CC       P97382; Q9JIP4: Panx1; NbExp=2; IntAct=EBI-7261133, EBI-6272917;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Strong expression in brain, with highest levels in
CC       neocortical and allocortical regions, hippocampus, olfactory bulb and
CC       cerebellum. Also strong in kidney. Weak expression in lung, skeletal
CC       muscle and heart. {ECO:0000269|PubMed:8824288}.
CC   -!- DOMAIN: Alteration of functional properties of alpha subunit is
CC       mediated through N-terminal domain of beta subunit. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC       family. {ECO:0000305}.
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DR   EMBL; U65593; AAB37264.1; -; mRNA.
DR   AlphaFoldDB; P97382; -.
DR   SMR; P97382; -.
DR   IntAct; P97382; 1.
DR   MINT; P97382; -.
DR   STRING; 10090.ENSMUSP00000018614; -.
DR   iPTMnet; P97382; -.
DR   PhosphoSitePlus; P97382; -.
DR   MaxQB; P97382; -.
DR   PaxDb; P97382; -.
DR   PRIDE; P97382; -.
DR   ProteomicsDB; 301756; -.
DR   ABCD; P97382; 1 sequenced antibody.
DR   UCSC; uc007jpt.1; mouse.
DR   MGI; MGI:1336208; Kcnab3.
DR   eggNOG; KOG1575; Eukaryota.
DR   InParanoid; P97382; -.
DR   Reactome; R-MMU-1296072; Voltage gated Potassium channels.
DR   PRO; PR:P97382; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P97382; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR   GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR   GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IBA:GO_Central.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR005983; K_chnl_volt-dep_bsu_KCNAB.
DR   InterPro; IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
DR   InterPro; IPR005402; K_chnl_volt-dep_bsu_KCNAB3.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43150; PTHR43150; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR01580; KCNAB3CHANEL.
DR   PRINTS; PR01577; KCNABCHANNEL.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   TIGRFAMs; TIGR01293; Kv_beta; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Ion channel; Ion transport; Potassium; Potassium transport;
KW   Reference proteome; Transport; Voltage-gated channel.
FT   CHAIN           1..249
FT                   /note="Voltage-gated potassium channel subunit beta-3"
FT                   /id="PRO_0000148751"
SQ   SEQUENCE   249 AA;  27749 MW;  614844B35161D2EA CRC64;
     MSRGYGLIFS LKVVFTFLSL PHPPGLQGSL DRLQLEYVDI VFANRSDPNS PMEEIVRAMT
     YVINQGLALY WGTSRWSAAE IMEAYSMARQ FNLIPPVCEQ AENHFFQREK VEMQLPELYH
     KIGVGSVTWS PLACGLITSK YDGRVPDTCK ATVKGYQWLK EKVQSEEGKK QQARVMDLLP
     TARQLGCTVG QLAIAWCLRS EGVSSVLLGV SSAEQLMEHL GSLQVLSQLT PQTVVEIDAL
     LGNKSHSKK