ID   KCAB3_RAT               Reviewed;         404 AA.
AC   Q63494; Q2KML7;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Voltage-gated potassium channel subunit beta-3;
DE   AltName: Full=K(+) channel subunit beta-3;
DE   AltName: Full=Kv-beta-3;
DE   AltName: Full=RCK beta3;
GN   Name=Kcnab3; Synonyms=Ckbeta3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain cortex;
RX   PubMed=8549760; DOI=10.1016/0014-5793(95)01377-6;
RA   Heinemann S.H., Rettig J., Wunder F., Pongs O.;
RT   "Molecular and functional characterization of a rat brain Kv beta 3
RT   potassium channel subunit.";
RL   FEBS Lett. 377:383-389(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Brown Norway/Cub, SHR/OlaIpcv, and Wistar Hd; TISSUE=Testis;
RA   Liska F., Blachut S., Gosele C., Kren V., Krenova D., Hubner N.;
RT   "Positional cloning of rat hd.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory potassium channel protein which modulates the
CC       activity of the pore-forming alpha subunit. Alters the functional
CC       properties of Kv1.4 but not Kv1.1 or Kv1.5.
CC       {ECO:0000269|PubMed:8549760}.
CC   -!- SUBUNIT: Forms heteromultimeric complex with alpha subunits.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in brain. Strongest
CC       expression in olfactory bulb and thalamic nuclei. Not detected in
CC       heart, spleen, lung, liver, skeletal muscle, kidney and testis.
CC       {ECO:0000269|PubMed:8549760}.
CC   -!- DOMAIN: Alteration of functional properties of alpha subunit is
CC       mediated through N-terminal domain of beta subunit. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC       family. {ECO:0000305}.
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DR   EMBL; X76723; CAA54141.1; -; mRNA.
DR   EMBL; AY903239; AAX85369.1; -; Genomic_DNA.
DR   EMBL; AY903240; AAX85370.1; -; Genomic_DNA.
DR   EMBL; AY903241; AAX85371.1; -; Genomic_DNA.
DR   PIR; S68409; S68409.
DR   RefSeq; NP_113840.1; NM_031652.1.
DR   AlphaFoldDB; Q63494; -.
DR   SMR; Q63494; -.
DR   CORUM; Q63494; -.
DR   STRING; 10116.ENSRNOP00000011523; -.
DR   iPTMnet; Q63494; -.
DR   PhosphoSitePlus; Q63494; -.
DR   PaxDb; Q63494; -.
DR   PRIDE; Q63494; -.
DR   ABCD; Q63494; 1 sequenced antibody.
DR   Ensembl; ENSRNOT00000011523; ENSRNOP00000011523; ENSRNOG00000008480.
DR   GeneID; 58981; -.
DR   KEGG; rno:58981; -.
DR   UCSC; RGD:61830; rat.
DR   CTD; 9196; -.
DR   RGD; 61830; Kcnab3.
DR   eggNOG; KOG1575; Eukaryota.
DR   GeneTree; ENSGT00940000159306; -.
DR   HOGENOM; CLU_023205_2_0_1; -.
DR   InParanoid; Q63494; -.
DR   OMA; YSMINRW; -.
DR   OrthoDB; 1106773at2759; -.
DR   PhylomeDB; Q63494; -.
DR   TreeFam; TF324563; -.
DR   Reactome; R-RNO-1296072; Voltage gated Potassium channels.
DR   PRO; PR:Q63494; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000008480; Expressed in cerebellum and 6 other tissues.
DR   Genevisible; Q63494; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR   GO; GO:0004033; F:aldo-keto reductase (NADP) activity; IBA:GO_Central.
DR   GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:1901379; P:regulation of potassium ion transmembrane transport; IBA:GO_Central.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR005983; K_chnl_volt-dep_bsu_KCNAB.
DR   InterPro; IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
DR   InterPro; IPR005402; K_chnl_volt-dep_bsu_KCNAB3.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43150; PTHR43150; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR01580; KCNAB3CHANEL.
DR   PRINTS; PR01577; KCNABCHANNEL.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   TIGRFAMs; TIGR01293; Kv_beta; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Ion channel; Ion transport; Potassium; Potassium transport;
KW   Reference proteome; Transport; Voltage-gated channel.
FT   CHAIN           1..404
FT                   /note="Voltage-gated potassium channel subunit beta-3"
FT                   /id="PRO_0000148752"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  43690 MW;  7F39B80D15E71A03 CRC64;
     MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPVGGGH GNPPGGGGLG SKSRTAVVPR
     PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT FGSQISDETA EDLLTVAYEH
     GVNLFDTAEV YAAGKAERTL GNILKSKGWR RSSYVITTKI FWGGQAETER GLSRKHIIEG
     LQGSLDRLQL EYVDIVFANR SDPSSPMEEI VRAMTYVINQ GLALYWGTSR WSAAEIMEAY
     SMARQFNLIP PVCEQAENHF FQREKVEMQL PELYHKIGVG SVTWSPLACS LITSKYDGQV
     PDACKATVKG YQWLKEKVQS EDGKKQQARV TDLLPIAHQL GCTVAQLAIA WCLRSEGVSS
     VLLGVSSAEQ LMEHLGSLQV LGQLTPQTVM EIDALLGNKS HSKK