ID   KCAB3_XENLA             Reviewed;         401 AA.
AC   Q9PTM4; Q6INC2;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Voltage-gated potassium channel subunit beta-3;
DE   AltName: Full=K(+) channel subunit beta-3;
DE   AltName: Full=Kv-beta-3;
GN   Name=kcnab3; Synonyms=kvb-B, kvb4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Tadpole head;
RX   PubMed=10594054; DOI=10.1523/jneurosci.19-24-10706.1999;
RA   Lazaroff M.A., Hofmann A.D., Ribera A.B.;
RT   "Xenopus embryonic spinal neurons express potassium channel Kvbeta
RT   subunits.";
RL   J. Neurosci. 19:10706-10715(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-401.
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory potassium channel protein which modulates the
CC       activity of the pore-forming alpha subunit. Alters functional
CC       properties of Kv1.1 and Kv1.2. {ECO:0000269|PubMed:10594054}.
CC   -!- SUBUNIT: Forms heteromultimeric complex with alpha subunits.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expression first detected in brain and most
CC       anterior regions of spinal cord at embryonic stage 24 (26 hours). By
CC       stage 29 (35 hours) expression is also detected in posterior regions of
CC       spinal cord. {ECO:0000269|PubMed:10594054}.
CC   -!- DOMAIN: Alteration of functional properties of alpha subunit is
CC       mediated through N-terminal domain of beta subunit. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC       family. {ECO:0000305}.
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DR   EMBL; AF172145; AAD56313.1; -; mRNA.
DR   EMBL; BC072361; AAH72361.1; -; mRNA.
DR   RefSeq; XP_018109269.1; XM_018253780.1.
DR   AlphaFoldDB; Q9PTM4; -.
DR   SMR; Q9PTM4; -.
DR   GeneID; 373751; -.
DR   KEGG; xla:373751; -.
DR   CTD; 373751; -.
DR   Xenbase; XB-GENE-996888; kcnab3.L.
DR   OrthoDB; 1106773at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 373751; Expressed in brain and 7 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR005983; K_chnl_volt-dep_bsu_KCNAB.
DR   InterPro; IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
DR   InterPro; IPR005402; K_chnl_volt-dep_bsu_KCNAB3.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43150; PTHR43150; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR01580; KCNAB3CHANEL.
DR   PRINTS; PR01577; KCNABCHANNEL.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   TIGRFAMs; TIGR01293; Kv_beta; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Ion channel; Ion transport; Potassium; Potassium transport;
KW   Reference proteome; Transport; Voltage-gated channel.
FT   CHAIN           1..401
FT                   /note="Voltage-gated potassium channel subunit beta-3"
FT                   /id="PRO_0000148753"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  45001 MW;  E540BECFF3BEB969 CRC64;
     MQVSFACTEQ TLRSRTSEDR LCPSRPSGGQ NGVSMAQTKQ RTPPMGAKNH NQVLPLLSHI
     LRESTVKSTG MKYRNLGKSG LRVSCLGLGT WVTFGSQISD EVAENLMTVA YEHGVNLFDT
     AEVYAAGRAE RTLGKILKKK EWRRSSYVVT TKIYWGGQAE TERGLSRKHI IEGLRGSLER
     LQLDYVDIVF ANRMDPNSPM EEIVRAMTFV INQGMAMYWG TSRWSAMEIM EAYSVARQFN
     LIPPVCEQAE YHLFQREKVE TQLPELYHKI GVGSMTWSPL ACGLITGKYT DTVPEKSRAS
     FKGYHWLKEK AISQEGKKQH SKVKELHPIA DRLNCTVTQL AIAWCLRSEG VSSVLLGVSN
     IEQLLENLGA IQVLPHLTPQ LVTEIDQILG NKPNLKKDSR A