ID   KCD14_HUMAN             Reviewed;         255 AA.
AC   Q9BQ13; B2R9R8;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD14;
GN   Name=KCTD14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3B).
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-255 (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- INTERACTION:
CC       Q9BQ13; O75716: STK16; NbExp=4; IntAct=EBI-10189448, EBI-749295;
CC       Q9BQ13; P15884: TCF4; NbExp=3; IntAct=EBI-10189448, EBI-533224;
CC       Q9BQ13-2; O75716: STK16; NbExp=3; IntAct=EBI-12278688, EBI-749295;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9BQ13-1; Sequence=Displayed;
CC       Name=3b;
CC         IsoId=Q9BQ13-2; Sequence=VSP_054562;
CC       Name=2; Synonyms=NDUFC2-KCTD14;
CC         IsoId=E9PQ53-1; Sequence=External;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH01062.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH01929.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BX359005; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BX359005; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK313892; BAG36615.1; -; mRNA.
DR   EMBL; AP003032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471076; EAW75043.1; -; Genomic_DNA.
DR   EMBL; BC001062; AAH01062.1; ALT_INIT; mRNA.
DR   EMBL; BC001929; AAH01929.1; ALT_INIT; mRNA.
DR   CCDS; CCDS60908.1; -. [Q9BQ13-2]
DR   CCDS; CCDS8255.2; -. [Q9BQ13-1]
DR   RefSeq; NP_001269335.1; NM_001282406.1. [Q9BQ13-2]
DR   RefSeq; NP_076419.2; NM_023930.3. [Q9BQ13-1]
DR   AlphaFoldDB; Q9BQ13; -.
DR   SMR; Q9BQ13; -.
DR   BioGRID; 122436; 21.
DR   IntAct; Q9BQ13; 3.
DR   STRING; 9606.ENSP00000316482; -.
DR   iPTMnet; Q9BQ13; -.
DR   PhosphoSitePlus; Q9BQ13; -.
DR   BioMuta; KCTD14; -.
DR   DMDM; 251757290; -.
DR   EPD; Q9BQ13; -.
DR   jPOST; Q9BQ13; -.
DR   MassIVE; Q9BQ13; -.
DR   MaxQB; Q9BQ13; -.
DR   PaxDb; Q9BQ13; -.
DR   PeptideAtlas; Q9BQ13; -.
DR   PRIDE; Q9BQ13; -.
DR   ProteomicsDB; 3417; -.
DR   ProteomicsDB; 78608; -. [Q9BQ13-1]
DR   Antibodypedia; 45177; 215 antibodies from 17 providers.
DR   DNASU; 65987; -.
DR   Ensembl; ENST00000353172.6; ENSP00000316482.5; ENSG00000151364.17. [Q9BQ13-1]
DR   Ensembl; ENST00000533144.1; ENSP00000431155.1; ENSG00000151364.17. [Q9BQ13-2]
DR   GeneID; 65987; -.
DR   KEGG; hsa:65987; -.
DR   MANE-Select; ENST00000353172.6; ENSP00000316482.5; NM_023930.4; NP_076419.2.
DR   UCSC; uc001oyw.5; human. [Q9BQ13-1]
DR   CTD; 65987; -.
DR   GeneCards; KCTD14; -.
DR   HGNC; HGNC:23295; KCTD14.
DR   HPA; ENSG00000151364; Low tissue specificity.
DR   neXtProt; NX_Q9BQ13; -.
DR   OpenTargets; ENSG00000151364; -.
DR   PharmGKB; PA134875104; -.
DR   VEuPathDB; HostDB:ENSG00000151364; -.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000160762; -.
DR   HOGENOM; CLU_070345_1_0_1; -.
DR   InParanoid; Q9BQ13; -.
DR   OMA; YLRSNQV; -.
DR   OrthoDB; 1377258at2759; -.
DR   PhylomeDB; Q9BQ13; -.
DR   TreeFam; TF315332; -.
DR   PathwayCommons; Q9BQ13; -.
DR   SignaLink; Q9BQ13; -.
DR   BioGRID-ORCS; 65987; 20 hits in 1074 CRISPR screens.
DR   GenomeRNAi; 65987; -.
DR   Pharos; Q9BQ13; Tdark.
DR   PRO; PR:Q9BQ13; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9BQ13; protein.
DR   Bgee; ENSG00000151364; Expressed in parotid gland and 137 other tissues.
DR   Genevisible; Q9BQ13; HS.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..255
FT                   /note="BTB/POZ domain-containing protein KCTD14"
FT                   /id="PRO_0000191299"
FT   DOMAIN          33..130
FT                   /note="BTB"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..30
FT                   /note="Missing (in isoform 3b)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_054562"
SQ   SEQUENCE   255 AA;  29591 MW;  8CACBE1B28951536 CRC64;
     MWQGCAVERP VGRMTSQTPL PQSPRPRRPT MSTVVELNVG GEFHTTTLGT LRKFPGSKLA
     EMFSSLAKAS TDAEGRFFID RPSTYFRPIL DYLRTGQVPT QHIPEVYREA QFYEIKPLVK
     LLEDMPQIFG EQVSRKQFLL QVPGYSENLE LMVRLARAEA ITARKSSVLV CLVETEEQDA
     YYSEVLCFLQ DKKMFKSVVK FGPWKAVLDN SDLMHCLEMD IKAQGYKVFS KFYLTYPTKR
     NEFHFNIYSF TFTWW