ID   KCD15_BOVIN             Reviewed;         283 AA.
AC   Q0VD00;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD15;
DE   AltName: Full=Potassium channel tetramerization domain-containing protein 15;
GN   Name=KCTD15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: During embryonic development, interferes with neural crest
CC       formation. Inhibits AP2 transcriptional activity by interaction with
CC       its activation domain (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TFAP2A; this interaction inhibits TFAP2A
CC       transcriptional activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K0E1}. Note=In
CC       the brain, localizes to the arcuate hypothalamic nucleus, the
CC       ventromedial hypothalamic nucleus and the accumbens nucleus of the
CC       ventral striatum. {ECO:0000250|UniProtKB:Q8K0E1}.
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DR   EMBL; BT029851; ABM06106.1; -; mRNA.
DR   EMBL; BC119910; AAI19911.1; -; mRNA.
DR   RefSeq; NP_001069036.1; NM_001075568.1.
DR   RefSeq; XP_005218995.1; XM_005218938.2.
DR   RefSeq; XP_005218996.1; XM_005218939.3.
DR   RefSeq; XP_015313543.1; XM_015458057.1.
DR   AlphaFoldDB; Q0VD00; -.
DR   SMR; Q0VD00; -.
DR   STRING; 9913.ENSBTAP00000023874; -.
DR   PaxDb; Q0VD00; -.
DR   Ensembl; ENSBTAT00000023874; ENSBTAP00000023874; ENSBTAG00000017956.
DR   GeneID; 512578; -.
DR   KEGG; bta:512578; -.
DR   CTD; 79047; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017956; -.
DR   VGNC; VGNC:30504; KCTD15.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00940000159496; -.
DR   HOGENOM; CLU_061268_1_0_1; -.
DR   InParanoid; Q0VD00; -.
DR   OMA; CREDRRM; -.
DR   OrthoDB; 971350at2759; -.
DR   TreeFam; TF315332; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000017956; Expressed in myometrium and 104 other tissues.
DR   ExpressionAtlas; Q0VD00; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18388; BTB_POZ_KCTD15; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR045904; KCTD15_T1-type_BTB.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..283
FT                   /note="BTB/POZ domain-containing protein KCTD15"
FT                   /id="PRO_0000281150"
FT   DOMAIN          56..126
FT                   /note="BTB"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96SI1"
FT   MOD_RES         35
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96SI1"
FT   MOD_RES         38
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96SI1"
SQ   SEQUENCE   283 AA;  31885 MW;  26B6323799EF79CC CRC64;
     MPHRKERPSG SSLHAHGSTG TAEGGSMSRL SLTRSPVSPL AAQGIPLPAQ LTKSNAPVHI
     DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYVLSFLRTS
     KLLLPDDFKD FSLLYEEARY YQLQPMVREL ERWQQEQEQR RRSRACDCLV VRVTPDLGER
     IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG
     FSVAASCGGG VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD