ID   KCD15_DANRE             Reviewed;         257 AA.
AC   Q6DC02;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=BTB/POZ domain-containing protein kctd15;
DE   AltName: Full=Potassium channel tetramerization domain-containing protein 15;
GN   Name=kctd15; ORFNames=zgc:100865;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND INTERACTION WITH TFAP2A.
RX   PubMed=23382213; DOI=10.1073/pnas.1300203110;
RA   Zarelli V.E., Dawid I.B.;
RT   "Inhibition of neural crest formation by Kctd15 involves regulation of
RT   transcription factor AP-2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:2870-2875(2013).
CC   -!- FUNCTION: During embryonic development, interferes with neural crest
CC       formation. Inhibits AP2 transcriptional activity by interaction with
CC       its activation domain. {ECO:0000269|PubMed:23382213}.
CC   -!- SUBUNIT: Interacts with tfap2a; this interaction inhibits TFAP2A
CC       transcriptional activation. {ECO:0000269|PubMed:23382213}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K0E1}.
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DR   EMBL; BC078294; AAH78294.1; -; mRNA.
DR   RefSeq; NP_001003527.1; NM_001003527.1.
DR   AlphaFoldDB; Q6DC02; -.
DR   SMR; Q6DC02; -.
DR   BioGRID; 92307; 1.
DR   GeneID; 445133; -.
DR   KEGG; dre:445133; -.
DR   CTD; 445133; -.
DR   ZFIN; ZDB-GENE-040801-34; kctd15b.
DR   InParanoid; Q6DC02; -.
DR   OrthoDB; 971350at2759; -.
DR   PRO; PR:Q6DC02; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0007420; P:brain development; IGI:ZFIN.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IGI:ZFIN.
DR   GO; GO:0014033; P:neural crest cell differentiation; IGI:ZFIN.
DR   GO; GO:0060037; P:pharyngeal system development; IGI:ZFIN.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18388; BTB_POZ_KCTD15; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR045904; KCTD15_T1-type_BTB.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="BTB/POZ domain-containing protein kctd15"
FT                   /id="PRO_0000247254"
FT   DOMAIN          30..100
FT                   /note="BTB"
SQ   SEQUENCE   257 AA;  29310 MW;  8C00645603531691 CRC64;
     MSRLSLTRSP VSPLAAQGIP LPAQLTKANA PVHIDVGGHM YTSSLATLTK YPDSRISRLF
     NGTEPIVLDS LKQHYFIDRD GEIFRYILSF LRTCKLLLPD DFKDFNLLYE EARYYQLSPM
     IKELERWKQE REQRRLANPC DCLVVRVTPD LGERIALSGE KVLIEEIFPE TGDVMCNSVN
     AGWNQDPTHV IRFPLNGYCR LNSVQVLERL FQKGFNVAAS CGGGVDSSQF SEYVLCREDR
     RSHNTNTPIR IKQEPLD