KCD15_MOUSE
ID KCD15_MOUSE Reviewed; 283 AA.
AC Q8K0E1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=BTB/POZ domain-containing protein KCTD15;
DE AltName: Full=Potassium channel tetramerization domain-containing protein 15;
GN Name=Kctd15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic breast;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-38, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=25187989; DOI=10.1371/journal.pgen.1004499;
RA Williams M.J., Goergen P., Rajendran J., Zheleznyakova G., Haegglund M.G.,
RA Perland E., Bagchi S., Kalogeropoulou A., Khan Z., Fredriksson R.,
RA Schioeth H.B.;
RT "Obesity-linked homologues TfAP-2 and Twz establish meal frequency in
RT Drosophila melanogaster.";
RL PLoS Genet. 10:e1004499-e1004499(2014).
CC -!- FUNCTION: During embryonic development, interferes with neural crest
CC formation. Inhibits AP2 transcriptional activity by interaction with
CC its activation domain (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TFAP2A; this interaction inhibits TFAP2A
CC transcriptional activation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25187989}. Note=In
CC the brain, localizes to the arcuate hypothalamic nucleus, the
CC ventromedial hypothalamic nucleus and the accumbens nucleus of the
CC ventral striatum. {ECO:0000269|PubMed:25187989}.
CC -!- TISSUE SPECIFICITY: Localizes to neurons in areas of the cerebral
CC cortex, cerebellum and hypothalamus (at protein level).
CC {ECO:0000269|PubMed:25187989}.
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DR EMBL; AK034731; BAC28810.1; -; mRNA.
DR EMBL; BC031749; AAH31749.1; -; mRNA.
DR CCDS; CCDS21141.1; -.
DR RefSeq; NP_666300.1; NM_146188.1.
DR RefSeq; XP_006539963.1; XM_006539900.1.
DR RefSeq; XP_006539964.1; XM_006539901.3.
DR RefSeq; XP_006539965.1; XM_006539902.3.
DR RefSeq; XP_006539966.1; XM_006539903.3.
DR RefSeq; XP_006539967.1; XM_006539904.3.
DR RefSeq; XP_006539968.1; XM_006539905.1.
DR AlphaFoldDB; Q8K0E1; -.
DR SMR; Q8K0E1; -.
DR IntAct; Q8K0E1; 1.
DR STRING; 10090.ENSMUSP00000103705; -.
DR iPTMnet; Q8K0E1; -.
DR PhosphoSitePlus; Q8K0E1; -.
DR MaxQB; Q8K0E1; -.
DR PaxDb; Q8K0E1; -.
DR PeptideAtlas; Q8K0E1; -.
DR PRIDE; Q8K0E1; -.
DR ProteomicsDB; 301758; -.
DR Antibodypedia; 29083; 256 antibodies from 29 providers.
DR DNASU; 233107; -.
DR Ensembl; ENSMUST00000032709; ENSMUSP00000032709; ENSMUSG00000030499.
DR Ensembl; ENSMUST00000108069; ENSMUSP00000103704; ENSMUSG00000030499.
DR Ensembl; ENSMUST00000108070; ENSMUSP00000103705; ENSMUSG00000030499.
DR GeneID; 233107; -.
DR KEGG; mmu:233107; -.
DR UCSC; uc009gjf.2; mouse.
DR CTD; 79047; -.
DR MGI; MGI:2385276; Kctd15.
DR VEuPathDB; HostDB:ENSMUSG00000030499; -.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000159496; -.
DR HOGENOM; CLU_061268_1_0_1; -.
DR InParanoid; Q8K0E1; -.
DR OMA; CREDRRM; -.
DR OrthoDB; 971350at2759; -.
DR PhylomeDB; Q8K0E1; -.
DR TreeFam; TF315332; -.
DR BioGRID-ORCS; 233107; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Kctd15; mouse.
DR PRO; PR:Q8K0E1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8K0E1; protein.
DR Bgee; ENSMUSG00000030499; Expressed in ear vesicle and 215 other tissues.
DR ExpressionAtlas; Q8K0E1; baseline and differential.
DR Genevisible; Q8K0E1; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18388; BTB_POZ_KCTD15; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR045904; KCTD15_T1-type_BTB.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..283
FT /note="BTB/POZ domain-containing protein KCTD15"
FT /id="PRO_0000247252"
FT DOMAIN 56..126
FT /note="BTB"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96SI1"
FT MOD_RES 35
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 283 AA; 31886 MW; 7D67029CD51B8E2B CRC64;
MPHRKERPSG SSLNAHGSSG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ LTKANAPVHI
DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYILSFLRTS
KLLLPDDFKD FNLLYEEARY YQLQPMVREL ERWQQDQEQR RRSRACDCLV VRVTPDLGER
IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG
FSVAASCGGG VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD
