ID   KCD15_XENLA             Reviewed;         255 AA.
AC   Q6DCX3;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=BTB/POZ domain-containing protein kctd15;
DE   AltName: Full=Potassium channel tetramerization domain-containing protein 15;
GN   Name=kctd15;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=23382213; DOI=10.1073/pnas.1300203110;
RA   Zarelli V.E., Dawid I.B.;
RT   "Inhibition of neural crest formation by Kctd15 involves regulation of
RT   transcription factor AP-2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:2870-2875(2013).
CC   -!- FUNCTION: During embryonic development, interferes with neural crest
CC       formation. Inhibits AP2 transcriptional activity by interaction with
CC       its activation domain. {ECO:0000269|PubMed:23382213}.
CC   -!- SUBUNIT: Interacts with TFAP2A; this interaction inhibits TFAP2A
CC       transcriptional activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K0E1}.
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DR   EMBL; BC077862; AAH77862.1; -; mRNA.
DR   RefSeq; NP_001086987.1; NM_001093518.1.
DR   AlphaFoldDB; Q6DCX3; -.
DR   SMR; Q6DCX3; -.
DR   DNASU; 446822; -.
DR   GeneID; 446822; -.
DR   KEGG; xla:446822; -.
DR   CTD; 446822; -.
DR   Xenbase; XB-GENE-944074; kctd15.L.
DR   OMA; CREDRRM; -.
DR   OrthoDB; 971350at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446822; Expressed in zone of skin and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..255
FT                   /note="BTB/POZ domain-containing protein kctd15"
FT                   /id="PRO_0000247255"
FT   DOMAIN          30..100
FT                   /note="BTB"
SQ   SEQUENCE   255 AA;  29174 MW;  47E4AF86F0EFEDCD CRC64;
     MSRLSLTRSP VSPLAAQGIP LPAQLTKSNA PVHLDVGGHM YTSSLATLTK YPDSRISRLF
     NGTEPIVLDS LKQHYFIDRD GEIFRYILSF LRTSKLLLPE DFKEINLLYE EAKYYQLLPM
     VKELERWKQD KEHRKHFQPC DCLVVRVTPD LGERIALSGE KALIEEIFPE TGDVMCNSVN
     AGWNQDPTHV IRFPLNGYCR LNSVQVLERL FQKGFHVAAS CGGGVDSSQF SEYVLCREDR
     RMQPNTMRIK QEPLD