KCD19_HUMAN
ID KCD19_HUMAN Reviewed; 926 AA.
AC Q17RG1; B4DZ49; Q8N804;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=BTB/POZ domain-containing protein KCTD19;
GN Name=KCTD19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Identified in a complex with ZNF541, HDAC1 and HSPA2.
CC {ECO:0000250|UniProtKB:Q562E2}.
CC -!- INTERACTION:
CC Q17RG1; P10073: ZSCAN22; NbExp=3; IntAct=EBI-10239046, EBI-10178224;
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DR EMBL; AK097481; BAC05072.1; -; mRNA.
DR EMBL; AK302748; BAG63961.1; -; mRNA.
DR EMBL; BC117335; AAI17336.1; -; mRNA.
DR CCDS; CCDS42179.1; -.
DR RefSeq; NP_001094385.1; NM_001100915.2.
DR AlphaFoldDB; Q17RG1; -.
DR SMR; Q17RG1; -.
DR BioGRID; 126971; 4.
DR IntAct; Q17RG1; 1.
DR STRING; 9606.ENSP00000305702; -.
DR iPTMnet; Q17RG1; -.
DR PhosphoSitePlus; Q17RG1; -.
DR BioMuta; KCTD19; -.
DR DMDM; 121948228; -.
DR MassIVE; Q17RG1; -.
DR PaxDb; Q17RG1; -.
DR PeptideAtlas; Q17RG1; -.
DR PRIDE; Q17RG1; -.
DR ProteomicsDB; 61152; -.
DR Antibodypedia; 56054; 109 antibodies from 17 providers.
DR DNASU; 146212; -.
DR Ensembl; ENST00000304372.6; ENSP00000305702.5; ENSG00000168676.11.
DR GeneID; 146212; -.
DR KEGG; hsa:146212; -.
DR MANE-Select; ENST00000304372.6; ENSP00000305702.5; NM_001100915.3; NP_001094385.1.
DR UCSC; uc002esu.3; human.
DR CTD; 146212; -.
DR DisGeNET; 146212; -.
DR GeneCards; KCTD19; -.
DR HGNC; HGNC:24753; KCTD19.
DR HPA; ENSG00000168676; Tissue enriched (testis).
DR neXtProt; NX_Q17RG1; -.
DR OpenTargets; ENSG00000168676; -.
DR PharmGKB; PA142671640; -.
DR VEuPathDB; HostDB:ENSG00000168676; -.
DR eggNOG; KOG0342; Eukaryota.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00390000007606; -.
DR HOGENOM; CLU_014244_0_0_1; -.
DR InParanoid; Q17RG1; -.
DR OMA; PRHWGAH; -.
DR OrthoDB; 1051383at2759; -.
DR PhylomeDB; Q17RG1; -.
DR TreeFam; TF315332; -.
DR PathwayCommons; Q17RG1; -.
DR SignaLink; Q17RG1; -.
DR BioGRID-ORCS; 146212; 12 hits in 1068 CRISPR screens.
DR ChiTaRS; KCTD19; human.
DR GenomeRNAi; 146212; -.
DR Pharos; Q17RG1; Tdark.
DR PRO; PR:Q17RG1; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q17RG1; protein.
DR Bgee; ENSG00000168676; Expressed in right testis and 122 other tissues.
DR ExpressionAtlas; Q17RG1; baseline and differential.
DR Genevisible; Q17RG1; HS.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 2.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR SUPFAM; SSF54695; SSF54695; 3.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..926
FT /note="BTB/POZ domain-containing protein KCTD19"
FT /id="PRO_0000313587"
FT DOMAIN 18..72
FT /note="BTB 1"
FT DOMAIN 398..485
FT /note="BTB 2"
FT REGION 673..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q562E2"
FT VARIANT 750
FT /note="E -> K (in dbSNP:rs16957289)"
FT /id="VAR_049723"
FT CONFLICT 579
FT /note="A -> V (in Ref. 1; BAC05072)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 926 AA; 104938 MW; 7F0E610073D551CE CRC64;
MEESGMAHES AEDLFHFNVG GWHFSVPRSK LSQFPDSLLW KEASALTSSE SQRLFIDRDG
STFRHVHYYL YTSKLSFSSC AELNLLYEQA LGLQLMPLLQ TLDNLKEGKH HLRVRPADLP
VAERASLNYW RTWKCISKPS EFPIKSPAFT GLHDKAPLGL MDTPLLDTEE EVHYCFLPLD
LVAKYPSLVT EDNLLWLAET VALIECECSE FRFIVNFLRS QKILLPDNFS NIDVLEAEVE
ILEIPALTEA VRWYRMNMGG CSPTTCSPLS PGKGARTASL ESVKPLYTMA LGLLVKYPDS
ALGQLRIEST LDGSRLYITG NGVLFQHVKN WLGTCRLPLT ETISEVYELC AFLDKRDITY
EPIKVALKTH LEPRTLAPMD VLNEWTAEIT VYSPQQIIKV YVGSHWYATT LQTLLKYPEL
LSNPQRVYWI TYGQTLLIHG DGQMFRHILN FLRLGKLFLP SEFKEWPLFC QEVEEYHIPS
LSEALAQCEA YKSWTQEKES ENEEAFSIRR LHVVTEGPGS LVEFSRDTKE TTAYMPVDFE
DCSDRTPWNK AKGNLVRSNQ MDEAEQYTRP IQVSLCRNAK RAGNPSTYSH CRGLCTNPGH
WGSHPESPPK KKCTTINLTQ KSETKDPPAT PMQKLISLVR EWDMVNCKQW EFQPLTATRS
SPLEEATLQL PLGSEAASQP STSAAWKAHS TASEKDPGPQ AGAGAGAKDK GPEPTFKPYL
PPKRAGTLKD WSKQRTKERE SPAPEQPLPE ASEVDSLGVI LKVTHPPVVG SDGFCMFFED
SIIYTTEMDN LRHTTPTASP QPQEVTFLSF SLSWEEMFYA QKCHCFLADI IMDSIRQKDP
KAITAKVVSL ANRLWTLHIS PKQFVVDLLA ITGFKDDRHT QERLYSWVEL TLPFARKYGR
CMDLLIQRGL SRSVSYSILG KYLQED
