KCD19_MOUSE
ID KCD19_MOUSE Reviewed; 927 AA.
AC Q562E2; Q8C628;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=BTB/POZ domain-containing protein KCTD19;
GN Name=Kctd19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBUNIT, IDENTIFICATION IN A COMPLEX WITH ZNF541; HDAC1 AND HSPA2,
RP IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RX PubMed=18849567; DOI=10.1074/jbc.m805590200;
RA Choi E., Han C., Park I., Lee B., Jin S., Choi H., Kim do H., Park Z.Y.,
RA Eddy E.M., Cho C.;
RT "A novel germ cell-specific protein, SHIP1, forms a complex with chromatin
RT remodeling activity during spermatogenesis.";
RL J. Biol. Chem. 283:35283-35294(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Identified in a complex with ZNF541, HDAC1 and HSPA2.
CC {ECO:0000269|PubMed:18849567}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q562E2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q562E2-2; Sequence=VSP_030044;
CC -!- TISSUE SPECIFICITY: Detected in adult testis.
CC {ECO:0000269|PubMed:18849567}.
CC -!- DEVELOPMENTAL STAGE: Not detected in testis from neonates. Expression
CC in testis is first detected 14 days after birth and increases
CC thereafter. Highly expressed 30 and 84 days after birth.
CC {ECO:0000269|PubMed:18849567}.
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DR EMBL; AK076644; BAC36433.1; -; mRNA.
DR EMBL; BC092530; AAH92530.1; -; mRNA.
DR EMBL; BC125431; AAI25432.1; -; mRNA.
DR EMBL; BC125433; AAI25434.1; -; mRNA.
DR CCDS; CCDS40459.1; -. [Q562E2-2]
DR CCDS; CCDS80922.1; -. [Q562E2-1]
DR RefSeq; NP_001288102.1; NM_001301173.1. [Q562E2-1]
DR RefSeq; NP_808459.1; NM_177791.3. [Q562E2-2]
DR AlphaFoldDB; Q562E2; -.
DR SMR; Q562E2; -.
DR BioGRID; 235004; 1.
DR CORUM; Q562E2; -.
DR STRING; 10090.ENSMUSP00000050687; -.
DR iPTMnet; Q562E2; -.
DR PhosphoSitePlus; Q562E2; -.
DR PaxDb; Q562E2; -.
DR PRIDE; Q562E2; -.
DR ProteomicsDB; 301760; -. [Q562E2-1]
DR ProteomicsDB; 301761; -. [Q562E2-2]
DR Antibodypedia; 56054; 109 antibodies from 17 providers.
DR Ensembl; ENSMUST00000063071; ENSMUSP00000050687; ENSMUSG00000051648. [Q562E2-2]
DR Ensembl; ENSMUST00000167294; ENSMUSP00000130831; ENSMUSG00000051648. [Q562E2-1]
DR GeneID; 279499; -.
DR KEGG; mmu:279499; -.
DR UCSC; uc009ncy.2; mouse. [Q562E2-2]
DR UCSC; uc009ncz.2; mouse. [Q562E2-1]
DR CTD; 146212; -.
DR MGI; MGI:3045294; Kctd19.
DR VEuPathDB; HostDB:ENSMUSG00000051648; -.
DR eggNOG; KOG0342; Eukaryota.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00390000007606; -.
DR HOGENOM; CLU_014244_0_0_1; -.
DR InParanoid; Q562E2; -.
DR OMA; PRHWGAH; -.
DR OrthoDB; 1051383at2759; -.
DR PhylomeDB; Q562E2; -.
DR TreeFam; TF315332; -.
DR BioGRID-ORCS; 279499; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Kctd19; mouse.
DR PRO; PR:Q562E2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q562E2; protein.
DR Bgee; ENSMUSG00000051648; Expressed in spermatocyte and 17 other tissues.
DR ExpressionAtlas; Q562E2; baseline and differential.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 3.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR Pfam; PF02214; BTB_2; 1.
DR SUPFAM; SSF54695; SSF54695; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..927
FT /note="BTB/POZ domain-containing protein KCTD19"
FT /id="PRO_0000313588"
FT DOMAIN 18..72
FT /note="BTB 1"
FT DOMAIN 399..486
FT /note="BTB 2"
FT REGION 664..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 258
FT /note="M -> MALQPALPGPKGSQLSLEQEEPSL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_030044"
FT CONFLICT 906
FT /note="L -> V (in Ref. 2; AAH92530)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 927 AA; 104820 MW; C0BF5261D8EA027E CRC64;
MEEPGGLHES AEDLFHFNVG GWHFSVPRSK LAQFPDSLLW KEASALTSSE NQRLFIDRDG
STFRHVHYYL YTSKLSFSSC AELNLLYEQA LGLQLMPLLQ TLDNLKEGRH HLRVRPADIP
VAERASLNYW RTWKCISKPS DFPIKSPAFT GLHDKAPLGL MDTPLLDTEE EVHYCFLPLD
LVAKYPSLVT EDNLLWLAET VALIECECSE FRFIVNFLRS HKILLPDNFS NIDVLEAEVE
ILEIPELTEA VRLYRMNMGG CSRTSCPPLS PGKGGRTASV ESVKPLYLMA LGLLVKYPDS
ALGQLRIEST LDGSRLYITG NGALFQHVRN WLGTCRLPLT ETISEVYELC AFLDKRDITY
EPMKVALKTH LEPRTLLPVD VLSEEWTAEV TIYSPQQIIK LYVGSHWYAT TLQTLMKYPE
LLSNTQRVYW IAYGQTLLIH GDGQMFRHIL NFLRLGKLFL PSEFKEWPLF CQEVEEYHIP
ALSEALAQCE AYKSWTQEKE SENEEAFPIR KLHVVTEGTG PMAEFSRDAK ETTACMPVDF
QECSDRTPWN KAKGNLTRSS QMEEAEQYTR TIQVSLCRNA KRGGNPSTYS HCSGLCANPR
HWGGHSESPP KKKCTTINLT QKPDAKDPPV TPMQKLISLV REWDMVNCKQ WEFQPLPASR
SSSVEEASLH VPSGSEAAPQ PGTSAAWKAH SITSEKDAGP QTGPGAGVKD KGPEPTFKPY
FPTKRAITLK DWGKQRPKDR ESPAPEQPLP NANGTDNPGA ILKVAHPPVV GNDGSCMFFE
DSIIYTTQMD NIKHTSLTAS PQLREVTFLS FSLSWEEMFY AQKCHRFLTD IILDSIRQKD
PKAITAKVVS LAYRLWTLNI SPKQFVVDLL AIAGFKDDRH TQERLYSWVE LTLPFARKYG
RCVDLLIQRG LSRSVSYSVL GKYLHEG
