ID   KCE1B_HUMAN             Reviewed;         132 AA.
AC   A0A087WTH5;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 2.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Putative potassium voltage-gated channel subfamily E member 1B {ECO:0000305};
GN   Name=KCNE1B {ECO:0000305};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction. The corresponding gene
CC       is on a region of chromosome 21 that is known to be an artifactual
CC       duplication of another chromosome 21 region in the GRCh38 assembly.
CC       This entry may represent an artifactual copy of AC P15382.
CC       {ECO:0000305}.
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DR   EMBL; CU633980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS82655.1; -.
DR   RefSeq; NP_001316994.1; NM_001330065.1.
DR   AlphaFoldDB; A0A087WTH5; -.
DR   SMR; A0A087WTH5; -.
DR   STRING; 9606.ENSP00000485125; -.
DR   GlyGen; A0A087WTH5; 2 sites.
DR   BioMuta; KCNE1B; -.
DR   Antibodypedia; 78187; 2 antibodies from 2 providers.
DR   DNASU; 102723475; -.
DR   GeneID; 102723475; -.
DR   KEGG; hsa:102723475; -.
DR   UCSC; uc032psk.2; human.
DR   DisGeNET; 102723475; -.
DR   GeneCards; KCNE1B; -.
DR   HPA; ENSG00000276289; Tissue enhanced (choroid plexus, fallopian tube, heart muscle).
DR   neXtProt; NX_A0A087WTH5; -.
DR   OpenTargets; ENSG00000276289; -.
DR   VEuPathDB; HostDB:ENSG00000276289; -.
DR   eggNOG; ENOG502SG7D; Eukaryota.
DR   GeneTree; ENSGT00940000154497; -.
DR   HOGENOM; CLU_159026_0_0_1; -.
DR   OrthoDB; 1452030at2759; -.
DR   BioGRID-ORCS; 102723475; 0 hits in 4 CRISPR screens.
DR   GenomeRNAi; 102723475; -.
DR   Pharos; A0A087WTH5; Tdark.
DR   PRO; PR:A0A087WTH5; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; A0A087WTH5; protein.
DR   Bgee; ENSG00000276289; Expressed in olfactory segment of nasal mucosa and 66 other tissues.
DR   ExpressionAtlas; A0A087WTH5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0086011; P:membrane repolarization during action potential; IBA:GO_Central.
DR   GO; GO:0098915; P:membrane repolarization during ventricular cardiac muscle cell action potential; IEA:GOC.
DR   GO; GO:1902260; P:negative regulation of delayed rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0097623; P:potassium ion export across plasma membrane; IBA:GO_Central.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IBA:GO_Central.
DR   GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IBA:GO_Central.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IBA:GO_Central.
DR   InterPro; IPR000369; K_chnl_KCNE.
DR   InterPro; IPR005424; KCNE1.
DR   PANTHER; PTHR15282; PTHR15282; 1.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   PRINTS; PR01604; KCNE1CHANNEL.
DR   PRINTS; PR00168; KCNECHANNEL.
PE   5: Uncertain;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..132
FT                   /note="Putative potassium voltage-gated channel subfamily E
FT                   member 1B"
FT                   /id="PRO_0000435849"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..132
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  15028 MW;  573FE641AB8FFBDC CRC64;
     MPRMILSNTT AVTPFLTKLW QETVQQGGNM SGLARRSPRS GDGKLEALYV LMVLGFFGFF
     TLGIMLSYIR SKKLEHSNDP FNVYIESNAW QEKDKAYVQA RVLESYRSCY VVENHLAIEQ
     PNTHLPETKP SP